Experience-dependent regulation of NG2 progenitors in the developing barrel cortex

We show that during formation of the mouse barrel cortex, NG2 cells receive glutamatergic synapses from thalamocortical fibers and preferentially accumulate along septa separating the barrels. Sensory deprivation reduces thalamocortical inputs on NG2 cells and increases their proliferation, leading...

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Autores principales: Mangin, Jean-Marie, Li, Peijun, Scafidi, Joseph, Gallo, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437334/
https://www.ncbi.nlm.nih.gov/pubmed/22885848
http://dx.doi.org/10.1038/nn.3190
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author Mangin, Jean-Marie
Li, Peijun
Scafidi, Joseph
Gallo, Vittorio
author_facet Mangin, Jean-Marie
Li, Peijun
Scafidi, Joseph
Gallo, Vittorio
author_sort Mangin, Jean-Marie
collection PubMed
description We show that during formation of the mouse barrel cortex, NG2 cells receive glutamatergic synapses from thalamocortical fibers and preferentially accumulate along septa separating the barrels. Sensory deprivation reduces thalamocortical inputs on NG2 cells and increases their proliferation, leading to a more uniform distribution within the deprived barrels. Therefore, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development.
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spelling pubmed-34373342013-03-01 Experience-dependent regulation of NG2 progenitors in the developing barrel cortex Mangin, Jean-Marie Li, Peijun Scafidi, Joseph Gallo, Vittorio Nat Neurosci Article We show that during formation of the mouse barrel cortex, NG2 cells receive glutamatergic synapses from thalamocortical fibers and preferentially accumulate along septa separating the barrels. Sensory deprivation reduces thalamocortical inputs on NG2 cells and increases their proliferation, leading to a more uniform distribution within the deprived barrels. Therefore, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development. 2012-08-12 2012-09 /pmc/articles/PMC3437334/ /pubmed/22885848 http://dx.doi.org/10.1038/nn.3190 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mangin, Jean-Marie
Li, Peijun
Scafidi, Joseph
Gallo, Vittorio
Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
title Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
title_full Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
title_fullStr Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
title_full_unstemmed Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
title_short Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
title_sort experience-dependent regulation of ng2 progenitors in the developing barrel cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437334/
https://www.ncbi.nlm.nih.gov/pubmed/22885848
http://dx.doi.org/10.1038/nn.3190
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