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GENETICS OF GENE EXPRESSION IN PRIMARY IMMUNE CELLS IDENTIFIES CELL-SPECIFIC MASTER REGULATORS AND ROLES OF HLA ALLELES

Trans-acting genetic variants play a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B-cells we identify novel, predominantly cell-specific, cis- and trans-eQTL (expression quantitative trait loci). These i...

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Detalles Bibliográficos
Autores principales:	Fairfax, Benjamin P, Makino, Seiko, Radhakrishnan, Jayachandran, Plant, Katharine, Leslie, Stephen, Dilthey, Alexander, Ellis, Peter, Langford, Cordelia, Vannberg, Fredrik O, Knight, Julian C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437404/ https://www.ncbi.nlm.nih.gov/pubmed/22446964 http://dx.doi.org/10.1038/ng.2205

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