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The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin
Activation-induced deaminase (AID) is a B lymphocyte-specific DNA deaminase that triggers Ig class-switch recombination (CSR) and somatic hypermutation. It shuttles between cytoplasm and nucleus, containing a nuclear export sequence (NES) at its carboxyterminus. Intriguingly, the precise nature of t...
Autores principales: | Ellyard, Julia I, Benk, Amelie S, Taylor, Benjamin, Rada, Cristina, Neuberger, Michael S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437479/ https://www.ncbi.nlm.nih.gov/pubmed/21268017 http://dx.doi.org/10.1002/eji.201041011 |
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