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The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin

Activation-induced deaminase (AID) is a B lymphocyte-specific DNA deaminase that triggers Ig class-switch recombination (CSR) and somatic hypermutation. It shuttles between cytoplasm and nucleus, containing a nuclear export sequence (NES) at its carboxyterminus. Intriguingly, the precise nature of t...

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Detalles Bibliográficos
Autores principales:	Ellyard, Julia I, Benk, Amelie S, Taylor, Benjamin, Rada, Cristina, Neuberger, Michael S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2011
Materias:	Molecular Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437479/ https://www.ncbi.nlm.nih.gov/pubmed/21268017 http://dx.doi.org/10.1002/eji.201041011

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