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DAMP signaling in fungal infections and diseases

Fungal infections and diseases predominantly affect patients with deregulated immunity. Compelling experimental and clinical evidence indicate that severe fungal diseases belong to the spectrum of fungus-related inflammatory diseases. Some degree of inflammation is required for protection during the...

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Autores principales: Cunha, Cristina, Carvalho, Agostinho, Esposito, Antonella, Bistoni, Francesco, Romani, Luigina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437516/
https://www.ncbi.nlm.nih.gov/pubmed/22973279
http://dx.doi.org/10.3389/fimmu.2012.00286
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author Cunha, Cristina
Carvalho, Agostinho
Esposito, Antonella
Bistoni, Francesco
Romani, Luigina
author_facet Cunha, Cristina
Carvalho, Agostinho
Esposito, Antonella
Bistoni, Francesco
Romani, Luigina
author_sort Cunha, Cristina
collection PubMed
description Fungal infections and diseases predominantly affect patients with deregulated immunity. Compelling experimental and clinical evidence indicate that severe fungal diseases belong to the spectrum of fungus-related inflammatory diseases. Some degree of inflammation is required for protection during the transitional response occurring temporally between the rapid innate and slower adaptive response. However, progressive inflammation worsens disease and ultimately prevents pathogen eradication. The challenge now is to elucidate cellular and molecular pathways distinguishing protective vs. pathogenic inflammation to fungi. In addition to fungal ligands of pattern recognition receptors (pathogen-associated molecular patterns, PAMPs), several host-encoded proteins, the damage-associated molecular patterns (DAMPs), are released during tissue injury and activate innate recognition receptors. DAMPs have been shown to regulate inflammation in fungal diseases. The DAMP/receptor for advanced glycation end-products axis integrated with the PAMP/Toll-like receptors axis in the generation of the inflammatory response in experimental and clinical fungal pneumonia. These emerging themes better accommodate fungal pathogenesis in the face of high-level inflammation seen in several clinical settings and point to DAMP targeting as a novel immunomodulatory strategy in fungal diseases.
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spelling pubmed-34375162012-09-12 DAMP signaling in fungal infections and diseases Cunha, Cristina Carvalho, Agostinho Esposito, Antonella Bistoni, Francesco Romani, Luigina Front Immunol Immunology Fungal infections and diseases predominantly affect patients with deregulated immunity. Compelling experimental and clinical evidence indicate that severe fungal diseases belong to the spectrum of fungus-related inflammatory diseases. Some degree of inflammation is required for protection during the transitional response occurring temporally between the rapid innate and slower adaptive response. However, progressive inflammation worsens disease and ultimately prevents pathogen eradication. The challenge now is to elucidate cellular and molecular pathways distinguishing protective vs. pathogenic inflammation to fungi. In addition to fungal ligands of pattern recognition receptors (pathogen-associated molecular patterns, PAMPs), several host-encoded proteins, the damage-associated molecular patterns (DAMPs), are released during tissue injury and activate innate recognition receptors. DAMPs have been shown to regulate inflammation in fungal diseases. The DAMP/receptor for advanced glycation end-products axis integrated with the PAMP/Toll-like receptors axis in the generation of the inflammatory response in experimental and clinical fungal pneumonia. These emerging themes better accommodate fungal pathogenesis in the face of high-level inflammation seen in several clinical settings and point to DAMP targeting as a novel immunomodulatory strategy in fungal diseases. Frontiers Research Foundation 2012-09-10 /pmc/articles/PMC3437516/ /pubmed/22973279 http://dx.doi.org/10.3389/fimmu.2012.00286 Text en Copyright © Cunha, Carvalho, Esposito, Bistoni and Romani. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Cunha, Cristina
Carvalho, Agostinho
Esposito, Antonella
Bistoni, Francesco
Romani, Luigina
DAMP signaling in fungal infections and diseases
title DAMP signaling in fungal infections and diseases
title_full DAMP signaling in fungal infections and diseases
title_fullStr DAMP signaling in fungal infections and diseases
title_full_unstemmed DAMP signaling in fungal infections and diseases
title_short DAMP signaling in fungal infections and diseases
title_sort damp signaling in fungal infections and diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437516/
https://www.ncbi.nlm.nih.gov/pubmed/22973279
http://dx.doi.org/10.3389/fimmu.2012.00286
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