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Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico

Multiple Sclerosis (MS) is a highly polymorphic disease characterized by different neurologic signs and symptoms. In MS, racial and genetic factors may play an important role in the geographic distribution of this disease. Studies have reported the presence of several protective alleles against the...

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Autores principales: Flores, Jose, González, Silvia, Morales, Ximena, Yescas, Petra, Ochoa, Adriana, Corona, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437645/
https://www.ncbi.nlm.nih.gov/pubmed/22973516
http://dx.doi.org/10.1155/2012/292631
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author Flores, Jose
González, Silvia
Morales, Ximena
Yescas, Petra
Ochoa, Adriana
Corona, Teresa
author_facet Flores, Jose
González, Silvia
Morales, Ximena
Yescas, Petra
Ochoa, Adriana
Corona, Teresa
author_sort Flores, Jose
collection PubMed
description Multiple Sclerosis (MS) is a highly polymorphic disease characterized by different neurologic signs and symptoms. In MS, racial and genetic factors may play an important role in the geographic distribution of this disease. Studies have reported the presence of several protective alleles against the development of autoimmune disorders. In the case of MS, however, they help define MS as a complex disease, and confirm the importance of environmental agents as an independent variable not associated with ethnicity. We carried out an on-site epidemiological study to confirm the absence of MS or NMO among Lacandonians, a pure Amerindian ethnic group in Mexico. We administered a structured interview to 5,372 Lacandonians to assess by family background any clinical data consistent with the presence of a prior demyelinating event. Every participating subject underwent a comprehensive neurological examination by a group of three members of the research team with experience in the diagnosis and treatment of demyelinating disorders to detect clinical signs compatible with a demyelinating disease. We did not find any clinical signs compatible with multiple sclerosis among study participants.
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spelling pubmed-34376452012-09-12 Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico Flores, Jose González, Silvia Morales, Ximena Yescas, Petra Ochoa, Adriana Corona, Teresa Mult Scler Int Clinical Study Multiple Sclerosis (MS) is a highly polymorphic disease characterized by different neurologic signs and symptoms. In MS, racial and genetic factors may play an important role in the geographic distribution of this disease. Studies have reported the presence of several protective alleles against the development of autoimmune disorders. In the case of MS, however, they help define MS as a complex disease, and confirm the importance of environmental agents as an independent variable not associated with ethnicity. We carried out an on-site epidemiological study to confirm the absence of MS or NMO among Lacandonians, a pure Amerindian ethnic group in Mexico. We administered a structured interview to 5,372 Lacandonians to assess by family background any clinical data consistent with the presence of a prior demyelinating event. Every participating subject underwent a comprehensive neurological examination by a group of three members of the research team with experience in the diagnosis and treatment of demyelinating disorders to detect clinical signs compatible with a demyelinating disease. We did not find any clinical signs compatible with multiple sclerosis among study participants. Hindawi Publishing Corporation 2012 2012-08-29 /pmc/articles/PMC3437645/ /pubmed/22973516 http://dx.doi.org/10.1155/2012/292631 Text en Copyright © 2012 Jose Flores et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Flores, Jose
González, Silvia
Morales, Ximena
Yescas, Petra
Ochoa, Adriana
Corona, Teresa
Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico
title Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico
title_full Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico
title_fullStr Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico
title_full_unstemmed Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico
title_short Absence of Multiple Sclerosis and Demyelinating Diseases among Lacandonians, a Pure Amerindian Ethnic Group in Mexico
title_sort absence of multiple sclerosis and demyelinating diseases among lacandonians, a pure amerindian ethnic group in mexico
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437645/
https://www.ncbi.nlm.nih.gov/pubmed/22973516
http://dx.doi.org/10.1155/2012/292631
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