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Sterile Endophthalmitis after Intravitreal Injections

Sterile endophthalmitis appears as an infrequent complication of intravitreal injections and seems to develop mainly in the context of the off-label use of drugs that have not been conceived for intravitreous administration. The aetiology of sterile endophthalmitis, independently of the administered...

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Autores principales: Marticorena, Joaquín, Romano, Vito, Gómez-Ulla, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437690/
https://www.ncbi.nlm.nih.gov/pubmed/22973075
http://dx.doi.org/10.1155/2012/928123
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author Marticorena, Joaquín
Romano, Vito
Gómez-Ulla, Francisco
author_facet Marticorena, Joaquín
Romano, Vito
Gómez-Ulla, Francisco
author_sort Marticorena, Joaquín
collection PubMed
description Sterile endophthalmitis appears as an infrequent complication of intravitreal injections and seems to develop mainly in the context of the off-label use of drugs that have not been conceived for intravitreous administration. The aetiology of sterile endophthalmitis, independently of the administered drug, remains uncertain and a multifactorial origin cannot be discarded. Sterile inflammation secondary both to intravitreal triamcinolone acetonide and to intravitreal bevacizumab share many characteristics such as the acute and painless vision loss present in the big majority of the cases. Dense vitreous opacity is a common factor, while anterior segment inflammation appears to be mild to moderate. In eyes with sterile endophthalmitis, visual acuity improves progressively as the intraocular inflammation reduces without any specific treatment. If by any chance the ophthalmologist is not convinced by the sterile origin of the inflammation, this complication must be treated as an acute endophthalmitis because of the devastating visual prognosis of this intraocular infection in the absence of therapy.
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spelling pubmed-34376902012-09-12 Sterile Endophthalmitis after Intravitreal Injections Marticorena, Joaquín Romano, Vito Gómez-Ulla, Francisco Mediators Inflamm Review Article Sterile endophthalmitis appears as an infrequent complication of intravitreal injections and seems to develop mainly in the context of the off-label use of drugs that have not been conceived for intravitreous administration. The aetiology of sterile endophthalmitis, independently of the administered drug, remains uncertain and a multifactorial origin cannot be discarded. Sterile inflammation secondary both to intravitreal triamcinolone acetonide and to intravitreal bevacizumab share many characteristics such as the acute and painless vision loss present in the big majority of the cases. Dense vitreous opacity is a common factor, while anterior segment inflammation appears to be mild to moderate. In eyes with sterile endophthalmitis, visual acuity improves progressively as the intraocular inflammation reduces without any specific treatment. If by any chance the ophthalmologist is not convinced by the sterile origin of the inflammation, this complication must be treated as an acute endophthalmitis because of the devastating visual prognosis of this intraocular infection in the absence of therapy. Hindawi Publishing Corporation 2012 2012-08-29 /pmc/articles/PMC3437690/ /pubmed/22973075 http://dx.doi.org/10.1155/2012/928123 Text en Copyright © 2012 Joaquín Marticorena et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Marticorena, Joaquín
Romano, Vito
Gómez-Ulla, Francisco
Sterile Endophthalmitis after Intravitreal Injections
title Sterile Endophthalmitis after Intravitreal Injections
title_full Sterile Endophthalmitis after Intravitreal Injections
title_fullStr Sterile Endophthalmitis after Intravitreal Injections
title_full_unstemmed Sterile Endophthalmitis after Intravitreal Injections
title_short Sterile Endophthalmitis after Intravitreal Injections
title_sort sterile endophthalmitis after intravitreal injections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437690/
https://www.ncbi.nlm.nih.gov/pubmed/22973075
http://dx.doi.org/10.1155/2012/928123
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