On the epigenetics of vascular regulation and disease

Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification of the epigenome by structural change...

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Autores principales: Schleithoff, Christina, Voelter-Mahlknecht, Susanne, Dahmke, Indra Navina, Mahlknecht, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438017/
https://www.ncbi.nlm.nih.gov/pubmed/22621747
http://dx.doi.org/10.1186/1868-7083-4-7
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author Schleithoff, Christina
Voelter-Mahlknecht, Susanne
Dahmke, Indra Navina
Mahlknecht, Ulrich
author_facet Schleithoff, Christina
Voelter-Mahlknecht, Susanne
Dahmke, Indra Navina
Mahlknecht, Ulrich
author_sort Schleithoff, Christina
collection PubMed
description Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification of the epigenome by structural changes of the chromatin architecture without alterations of the associated genomic DNA sequence is part of the cellular response to environmental changes. Such environmental conditions, which are finally being translated into adaptations of the cardiovascular system, also comprise pathological conditions such as atherosclerosis or myocardial infarction. This review summarizes recent findings on the epigenetics of vascular regulation and disease and presents nutritional and pharmacological approaches as novel epigenetic strategies in the prevention and treatment of cardiovascular disease.
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spelling pubmed-34380172012-09-11 On the epigenetics of vascular regulation and disease Schleithoff, Christina Voelter-Mahlknecht, Susanne Dahmke, Indra Navina Mahlknecht, Ulrich Clin Epigenetics Review Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. The modulation of gene expression through modification of the epigenome by structural changes of the chromatin architecture without alterations of the associated genomic DNA sequence is part of the cellular response to environmental changes. Such environmental conditions, which are finally being translated into adaptations of the cardiovascular system, also comprise pathological conditions such as atherosclerosis or myocardial infarction. This review summarizes recent findings on the epigenetics of vascular regulation and disease and presents nutritional and pharmacological approaches as novel epigenetic strategies in the prevention and treatment of cardiovascular disease. BioMed Central 2012-05-23 /pmc/articles/PMC3438017/ /pubmed/22621747 http://dx.doi.org/10.1186/1868-7083-4-7 Text en Copyright ©2012 Schleithoff et al.; licensee BioMed Central Ltd. http:// http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:// http://creativecommons.org/licenses/by/2.0 (http://http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Schleithoff, Christina
Voelter-Mahlknecht, Susanne
Dahmke, Indra Navina
Mahlknecht, Ulrich
On the epigenetics of vascular regulation and disease
title On the epigenetics of vascular regulation and disease
title_full On the epigenetics of vascular regulation and disease
title_fullStr On the epigenetics of vascular regulation and disease
title_full_unstemmed On the epigenetics of vascular regulation and disease
title_short On the epigenetics of vascular regulation and disease
title_sort on the epigenetics of vascular regulation and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438017/
https://www.ncbi.nlm.nih.gov/pubmed/22621747
http://dx.doi.org/10.1186/1868-7083-4-7
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