Cargando…

Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes

BACKGROUND: The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy. RESULTS: The extract of Cin...

Descripción completa

Detalles Bibliográficos
Autores principales: Voukeng, Igor K, Kuete, Victor, Dzoyem, Jean P, Fankam, Aimé G, Noumedem, Jaures A K, Kuiate, Jules R, Pages, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438083/
https://www.ncbi.nlm.nih.gov/pubmed/22709668
http://dx.doi.org/10.1186/1756-0500-5-299
_version_ 1782242863448326144
author Voukeng, Igor K
Kuete, Victor
Dzoyem, Jean P
Fankam, Aimé G
Noumedem, Jaures A K
Kuiate, Jules R
Pages, Jean-Marie
author_facet Voukeng, Igor K
Kuete, Victor
Dzoyem, Jean P
Fankam, Aimé G
Noumedem, Jaures A K
Kuiate, Jules R
Pages, Jean-Marie
author_sort Voukeng, Igor K
collection PubMed
description BACKGROUND: The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy. RESULTS: The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY). CONCLUSION: The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.
format Online
Article
Text
id pubmed-3438083
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34380832012-09-11 Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes Voukeng, Igor K Kuete, Victor Dzoyem, Jean P Fankam, Aimé G Noumedem, Jaures A K Kuiate, Jules R Pages, Jean-Marie BMC Res Notes Research Article BACKGROUND: The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy. RESULTS: The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY). CONCLUSION: The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria. BioMed Central 2012-06-15 /pmc/articles/PMC3438083/ /pubmed/22709668 http://dx.doi.org/10.1186/1756-0500-5-299 Text en Copyright ©2012 Voukeng et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Voukeng, Igor K
Kuete, Victor
Dzoyem, Jean P
Fankam, Aimé G
Noumedem, Jaures A K
Kuiate, Jules R
Pages, Jean-Marie
Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
title Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
title_full Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
title_fullStr Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
title_full_unstemmed Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
title_short Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
title_sort antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against gram-negative multi-drug resistant phenotypes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438083/
https://www.ncbi.nlm.nih.gov/pubmed/22709668
http://dx.doi.org/10.1186/1756-0500-5-299
work_keys_str_mv AT voukengigork antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes
AT kuetevictor antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes
AT dzoyemjeanp antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes
AT fankamaimeg antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes
AT noumedemjauresak antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes
AT kuiatejulesr antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes
AT pagesjeanmarie antibacterialandantibioticpotentiationactivitiesofthemethanolextractofsomecameroonianspicesagainstgramnegativemultidrugresistantphenotypes