Cargando…

Expression Profiling of Stem Cell-Related Genes in Neoadjuvant-Treated Gastric Cancer: A NOTCH2, GSK3B and β-catenin Gene Signature Predicts Survival

Cancer stem cell (CSC) based gene expression signatures are associated with prognosis in various tumour types and CSCs are suggested to be particularly drug resistant. The aim of our study was first, to determine the prognostic significance of CSC-related gene expression in residual tumour cells of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauer, Lukas, Langer, Rupert, Becker, Karen, Hapfelmeier, Alexander, Ott, Katja, Novotny, Alexander, Höfler, Heinz, Keller, Gisela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438181/ https://www.ncbi.nlm.nih.gov/pubmed/22970250 http://dx.doi.org/10.1371/journal.pone.0044566

Ejemplares similares

Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study
por: Bauer, Lukas, et al.
Publicado: (2015)

Diverse ‘just-right’ levels of chromosomal instability and their clinical implications in neoadjuvant treated gastric cancer
por: Kohlruss, Meike, et al.
Publicado: (2021)

Sexual Difference Matters: Females with High Microsatellite Instability Show Increased Survival after Neoadjuvant Chemotherapy in Gastric Cancer
por: Kohlruss, Meike, et al.
Publicado: (2021)

Significant Tumor Regression after Neoadjuvant Chemotherapy in Gastric Cancer, but Poor Survival of the Patient? Role of MHC Class I Alterations
por: Hiltner, Theresa, et al.
Publicado: (2023)

Prognostic implication of molecular subtypes and response to neoadjuvant chemotherapy in 760 gastric carcinomas: role of Epstein–Barr virus infection and high‐ and low‐microsatellite instability
por: Kohlruss, Meike, et al.
Publicado: (2019)

Microsatellite instability and sex-specific differences of survival in gastric cancer after neoadjuvant chemotherapy without and with taxane: An observational study in real world patients
por: Hiltner, Theresa, et al.
Publicado: (2023)

Post‐neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage‐ and regression‐grade independent prognostic information in intestinal‐type gastric adenocarcinoma
por: Jesinghaus, Moritz, et al.
Publicado: (2022)

A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients
por: Blank, Susanne, et al.
Publicado: (2014)

A microsatellite based multiplex PCR method for the detection of chromosomal instability in gastric cancer
por: Kohlruss, Meike, et al.
Publicado: (2018)

Impact of Tumor Localization and Molecular Subtypes on the Prognostic and Predictive Significance of p53 Expression in Gastric Cancer
por: Grosser, Bianca, et al.
Publicado: (2020)

A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas
por: Slotta-Huspenina, J, et al.
Publicado: (2013)

UICC Staging after Neoadjuvant/Perioperative Chemotherapy Reveals No Significant Survival Differences Compared to Primary Surgery for Locally Advanced Gastric Cancer
por: Dimpel, Rebekka, et al.
Publicado: (2022)

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity
por: Straub, Melanie, et al.
Publicado: (2016)

Significance of tumour regression in lymph node metastases of gastric and gastro‐oesophageal junction adenocarcinomas
por: Reim, Daniel, et al.
Publicado: (2020)

Notch-based gene signature for predicting the response to neoadjuvant chemotherapy in triple-negative breast cancer
por: Omar, Mohamed, et al.
Publicado: (2023)

Evidence of Prognostic Relevant Expression Profiles of Heat-Shock Proteins and Glucose-Regulated Proteins in Oesophageal Adenocarcinomas
por: Slotta-Huspenina, Julia, et al.
Publicado: (2012)

Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin
por: Xu, Ruoshi, et al.
Publicado: (2013)

Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy
por: Aichler, Michaela, et al.
Publicado: (2014)

Decision impact and feasibility of different ASCO-recommended biomarkers in early breast cancer: Prospective comparison of molecular marker EndoPredict and protein marker uPA/PAI-1
por: Ettl, Johannes, et al.
Publicado: (2017)

Association between HSP90 and Her2 in Gastric and Gastroesophageal Carcinomas
por: Berezowska, Sabina, et al.
Publicado: (2013)

Corrigendum to “Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin”
por: Xu, Ruoshi, et al.
Publicado: (2015)

Retracted: Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin
por: in Chemistry, Journal of Analytical Methods
Publicado: (2021)

Elevated microsatellite instability at selected tetranucleotide (EMAST) repeats in gastric cancer: a distinct microsatellite instability type with potential clinical impact?
por: Herz, Anna‐Lina, et al.
Publicado: (2022)

Neoadjuvant Treatment for Gastric Cancer
por: Schuhmacher, Christoph, et al.
Publicado: (2013)

Nonparametric Subgroup Identification by PRIM and CART: A Simulation and Application Study
por: Ott, Armin, et al.
Publicado: (2017)

Tumor Regression Grading of Gastrointestinal Carcinomas after Neoadjuvant Treatment
por: Thies, Svenja, et al.
Publicado: (2013)

Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
por: Luber, Birgit, et al.
Publicado: (2011)

High number of CD45RO+ tumor infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma
por: Rauser, Sandra, et al.
Publicado: (2010)

GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility
por: Fazil, Mobashar Hussain Urf Turabe, et al.
Publicado: (2021)

GSK3β Is Involved in JNK2-Mediated β-Catenin Inhibition
por: Hu, Dong, et al.
Publicado: (2009)

Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling
por: Sun, Jianjun, et al.
Publicado: (2008)

A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2018)

The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells
por: Abdul, Ata ur Rahman Mohammed, et al.
Publicado: (2017)

Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2019)

Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway
por: Pratap, Akshay, et al.
Publicado: (2022)

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling
por: Maher, Meghan T., et al.
Publicado: (2010)

Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas
por: Schmidt, T, et al.
Publicado: (2014)

Jagged1 Expression Regulated by Notch3 and Wnt/β-catenin Signaling Pathways in Ovarian Cancer
por: Chen, Xu, et al.
Publicado: (2010)

The GSK-3/β-catenin-signalling axis in smooth muscle and its relationship with remodelling
por: Gosens, Reinoud, et al.
Publicado: (2008)

Cordycepin Regulates GSK-3β/β-Catenin Signaling in Human Leukemia Cells
por: Ko, Bor-Sheng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1iga0mi1rparh62uaubsu7n49s