Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41

Identification of broadly cross-reactive HIV-1-neutralizing antibodies (bnAbs) may assist vaccine immunogen design. Here we report a novel human monoclonal antibody (mAb), designated m43, which co-targets the gp120 and gp41 subunits of the HIV-1 envelope glycoprotein (Env). M43 bound to recombinant...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mei-Yun, Yuan, Tingting, Li, Jingjing, Rosa Borges, Andrew, Watkins, Jennifer D., Guenaga, Javier, Yang, Zheng, Wang, Yanping, Wilson, Richard, Li, Yuxing, Polonis, Victoria R., Pincus, Seth H., Ruprecht, Ruth M., Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438192/
https://www.ncbi.nlm.nih.gov/pubmed/22970187
http://dx.doi.org/10.1371/journal.pone.0044241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438192/
https://www.ncbi.nlm.nih.gov/pubmed/22970187
http://dx.doi.org/10.1371/journal.pone.0044241

Ejemplares similares