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Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation

OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of...

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Autores principales: da Fonseca Ferraz, Mara Lúcia, Nascimento, Douglas Montielle Silva, Rorato, João Paulo Hanel, Espindula, Ana Paula, Oliveira, Lívia Ferreira, Ramalho, Luciana Santos, Soares, Maria Helena, Cavellani, Camila Lourencine, Oliveira, Flávia Aparecida, de Lima Pereira, Sanívia Aparecida, Corrêa, Rosana Rosa Miranda, de Paula Antunes Teixeira, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438249/
https://www.ncbi.nlm.nih.gov/pubmed/23018306
http://dx.doi.org/10.6061/clinics/2012(09)15
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author da Fonseca Ferraz, Mara Lúcia
Nascimento, Douglas Montielle Silva
Rorato, João Paulo Hanel
Espindula, Ana Paula
Oliveira, Lívia Ferreira
Ramalho, Luciana Santos
Soares, Maria Helena
Cavellani, Camila Lourencine
Oliveira, Flávia Aparecida
de Lima Pereira, Sanívia Aparecida
Corrêa, Rosana Rosa Miranda
de Paula Antunes Teixeira, Vicente
author_facet da Fonseca Ferraz, Mara Lúcia
Nascimento, Douglas Montielle Silva
Rorato, João Paulo Hanel
Espindula, Ana Paula
Oliveira, Lívia Ferreira
Ramalho, Luciana Santos
Soares, Maria Helena
Cavellani, Camila Lourencine
Oliveira, Flávia Aparecida
de Lima Pereira, Sanívia Aparecida
Corrêa, Rosana Rosa Miranda
de Paula Antunes Teixeira, Vicente
author_sort da Fonseca Ferraz, Mara Lúcia
collection PubMed
description OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and collagen depositions in the intima, and the infiltration of mast cells into the layers of the aorta. We correlated the findings with gender, age, race and cause of death. RESULTS: The degree of atherosclerosis was significantly higher in the elderly. The aorta was thicker in the elderly and in cases with a cardiovascular cause of death. The thickness of the intima was significantly greater in the elderly, in males and in cases with a cardiovascular cause of death. The lipid content in the intima of the aorta was significantly higher in Caucasians. Older people and men had a significantly higher number of mast cells. CONCLUSION: A macroscopic evaluation is a good indicator of the severity of atherosclerosis, but a more detailed analysis, namely evaluating the thickness of the layers of the aorta and the number of mast cells, may further elucidate the changes in the constituents of this vessel.
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spelling pubmed-34382492012-09-11 Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation da Fonseca Ferraz, Mara Lúcia Nascimento, Douglas Montielle Silva Rorato, João Paulo Hanel Espindula, Ana Paula Oliveira, Lívia Ferreira Ramalho, Luciana Santos Soares, Maria Helena Cavellani, Camila Lourencine Oliveira, Flávia Aparecida de Lima Pereira, Sanívia Aparecida Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente Clinics (Sao Paulo) Basic Research OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and collagen depositions in the intima, and the infiltration of mast cells into the layers of the aorta. We correlated the findings with gender, age, race and cause of death. RESULTS: The degree of atherosclerosis was significantly higher in the elderly. The aorta was thicker in the elderly and in cases with a cardiovascular cause of death. The thickness of the intima was significantly greater in the elderly, in males and in cases with a cardiovascular cause of death. The lipid content in the intima of the aorta was significantly higher in Caucasians. Older people and men had a significantly higher number of mast cells. CONCLUSION: A macroscopic evaluation is a good indicator of the severity of atherosclerosis, but a more detailed analysis, namely evaluating the thickness of the layers of the aorta and the number of mast cells, may further elucidate the changes in the constituents of this vessel. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012-09 /pmc/articles/PMC3438249/ /pubmed/23018306 http://dx.doi.org/10.6061/clinics/2012(09)15 Text en Copyright © 2012 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research
da Fonseca Ferraz, Mara Lúcia
Nascimento, Douglas Montielle Silva
Rorato, João Paulo Hanel
Espindula, Ana Paula
Oliveira, Lívia Ferreira
Ramalho, Luciana Santos
Soares, Maria Helena
Cavellani, Camila Lourencine
Oliveira, Flávia Aparecida
de Lima Pereira, Sanívia Aparecida
Corrêa, Rosana Rosa Miranda
de Paula Antunes Teixeira, Vicente
Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
title Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
title_full Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
title_fullStr Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
title_full_unstemmed Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
title_short Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
title_sort correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438249/
https://www.ncbi.nlm.nih.gov/pubmed/23018306
http://dx.doi.org/10.6061/clinics/2012(09)15
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