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Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation
OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438249/ https://www.ncbi.nlm.nih.gov/pubmed/23018306 http://dx.doi.org/10.6061/clinics/2012(09)15 |
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author | da Fonseca Ferraz, Mara Lúcia Nascimento, Douglas Montielle Silva Rorato, João Paulo Hanel Espindula, Ana Paula Oliveira, Lívia Ferreira Ramalho, Luciana Santos Soares, Maria Helena Cavellani, Camila Lourencine Oliveira, Flávia Aparecida de Lima Pereira, Sanívia Aparecida Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente |
author_facet | da Fonseca Ferraz, Mara Lúcia Nascimento, Douglas Montielle Silva Rorato, João Paulo Hanel Espindula, Ana Paula Oliveira, Lívia Ferreira Ramalho, Luciana Santos Soares, Maria Helena Cavellani, Camila Lourencine Oliveira, Flávia Aparecida de Lima Pereira, Sanívia Aparecida Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente |
author_sort | da Fonseca Ferraz, Mara Lúcia |
collection | PubMed |
description | OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and collagen depositions in the intima, and the infiltration of mast cells into the layers of the aorta. We correlated the findings with gender, age, race and cause of death. RESULTS: The degree of atherosclerosis was significantly higher in the elderly. The aorta was thicker in the elderly and in cases with a cardiovascular cause of death. The thickness of the intima was significantly greater in the elderly, in males and in cases with a cardiovascular cause of death. The lipid content in the intima of the aorta was significantly higher in Caucasians. Older people and men had a significantly higher number of mast cells. CONCLUSION: A macroscopic evaluation is a good indicator of the severity of atherosclerosis, but a more detailed analysis, namely evaluating the thickness of the layers of the aorta and the number of mast cells, may further elucidate the changes in the constituents of this vessel. |
format | Online Article Text |
id | pubmed-3438249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-34382492012-09-11 Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation da Fonseca Ferraz, Mara Lúcia Nascimento, Douglas Montielle Silva Rorato, João Paulo Hanel Espindula, Ana Paula Oliveira, Lívia Ferreira Ramalho, Luciana Santos Soares, Maria Helena Cavellani, Camila Lourencine Oliveira, Flávia Aparecida de Lima Pereira, Sanívia Aparecida Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente Clinics (Sao Paulo) Basic Research OBJECTIVES: To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation. METHOD: We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and collagen depositions in the intima, and the infiltration of mast cells into the layers of the aorta. We correlated the findings with gender, age, race and cause of death. RESULTS: The degree of atherosclerosis was significantly higher in the elderly. The aorta was thicker in the elderly and in cases with a cardiovascular cause of death. The thickness of the intima was significantly greater in the elderly, in males and in cases with a cardiovascular cause of death. The lipid content in the intima of the aorta was significantly higher in Caucasians. Older people and men had a significantly higher number of mast cells. CONCLUSION: A macroscopic evaluation is a good indicator of the severity of atherosclerosis, but a more detailed analysis, namely evaluating the thickness of the layers of the aorta and the number of mast cells, may further elucidate the changes in the constituents of this vessel. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012-09 /pmc/articles/PMC3438249/ /pubmed/23018306 http://dx.doi.org/10.6061/clinics/2012(09)15 Text en Copyright © 2012 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research da Fonseca Ferraz, Mara Lúcia Nascimento, Douglas Montielle Silva Rorato, João Paulo Hanel Espindula, Ana Paula Oliveira, Lívia Ferreira Ramalho, Luciana Santos Soares, Maria Helena Cavellani, Camila Lourencine Oliveira, Flávia Aparecida de Lima Pereira, Sanívia Aparecida Corrêa, Rosana Rosa Miranda de Paula Antunes Teixeira, Vicente Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
title | Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
title_full | Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
title_fullStr | Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
title_full_unstemmed | Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
title_short | Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
title_sort | correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438249/ https://www.ncbi.nlm.nih.gov/pubmed/23018306 http://dx.doi.org/10.6061/clinics/2012(09)15 |
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