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Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo

Host-generated oxidative stress is considered one of the main mechanisms constraining Mycobacterium tuberculosis (Mtb) growth. The redox-sensing mechanisms in Mtb are not completely understood. Here we show that WhiB4 responds to oxygen (O(2)) and nitric oxide (NO) via its 4Fe-4S cluster and control...

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Detalles Bibliográficos
Autores principales:	Chawla, Manbeena, Parikh, Pankti, Saxena, Alka, Munshi, MohamedHusen, Mehta, Mansi, Mai, Deborah, Srivastava, Anup K, Narasimhulu, K V, Redding, Kevin E, Vashi, Nimi, Kumar, Dhiraj, Steyn, Adrie J C, Singh, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438311/ https://www.ncbi.nlm.nih.gov/pubmed/22780904 http://dx.doi.org/10.1111/j.1365-2958.2012.08165.x

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