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The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial
OBJECTIVE: To evaluate the safety and potential efficacy of "recombinant human growth hormone (rhGH)" on the functional recovery of completed stroke patients. METHOD: Completed stroke patients were recruited. All participants were randomly assigned to the GH group (rhGH injection and rehab...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Academy of Rehabilitation Medicine
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438410/ https://www.ncbi.nlm.nih.gov/pubmed/22977769 http://dx.doi.org/10.5535/arm.2012.36.4.447 |
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author | Song, Junyoung Park, Kicheol Lee, Hakil Kim, MinYoung |
author_facet | Song, Junyoung Park, Kicheol Lee, Hakil Kim, MinYoung |
author_sort | Song, Junyoung |
collection | PubMed |
description | OBJECTIVE: To evaluate the safety and potential efficacy of "recombinant human growth hormone (rhGH)" on the functional recovery of completed stroke patients. METHOD: Completed stroke patients were recruited. All participants were randomly assigned to the GH group (rhGH injection and rehabilitative therapy) or the control group (only rehabilitative therapy). Above all, they were closely monitored for safety. Further, for the efficacy measurement, Korean Modified Barthel Index (K-MBI), Manual Muscle strength Test (MMT), and Fugl-Meyer assessment (FMA) were assessed to determine the changes of functional recovery during 6-months of the study period. Along with it, diffusion tensor image was taken as the baseline, and a followed-up study to observe the changes in diffusion tensor tractography (DTT), during the period, and one patient in the GH group was also examined with functional MRI (fMRI). Index of fatigue on 5 point scale for the study period was also assessed. RESULTS: Twenty-two patients were enrolled, and 15 completed the study and were included in the analysis. No harmful adverse events were observed in the GH group. By comparison between the groups, the GH group showed more improvement in K-MBI than the control group (p<0.05). DTT showed less decrement of fibers in the GH group than in the control group, without statistical significance. fMRI showed an increment in the activated area. Patients in the GH group expressed no fatigue at all, during the study period (p=0.00). CONCLUSION: The administration of rhGH in long term resulted in the improvement in K-MBI, and subjectively less tiredness during the injection period. |
format | Online Article Text |
id | pubmed-3438410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Academy of Rehabilitation Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-34384102012-09-13 The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial Song, Junyoung Park, Kicheol Lee, Hakil Kim, MinYoung Ann Rehabil Med Original Article OBJECTIVE: To evaluate the safety and potential efficacy of "recombinant human growth hormone (rhGH)" on the functional recovery of completed stroke patients. METHOD: Completed stroke patients were recruited. All participants were randomly assigned to the GH group (rhGH injection and rehabilitative therapy) or the control group (only rehabilitative therapy). Above all, they were closely monitored for safety. Further, for the efficacy measurement, Korean Modified Barthel Index (K-MBI), Manual Muscle strength Test (MMT), and Fugl-Meyer assessment (FMA) were assessed to determine the changes of functional recovery during 6-months of the study period. Along with it, diffusion tensor image was taken as the baseline, and a followed-up study to observe the changes in diffusion tensor tractography (DTT), during the period, and one patient in the GH group was also examined with functional MRI (fMRI). Index of fatigue on 5 point scale for the study period was also assessed. RESULTS: Twenty-two patients were enrolled, and 15 completed the study and were included in the analysis. No harmful adverse events were observed in the GH group. By comparison between the groups, the GH group showed more improvement in K-MBI than the control group (p<0.05). DTT showed less decrement of fibers in the GH group than in the control group, without statistical significance. fMRI showed an increment in the activated area. Patients in the GH group expressed no fatigue at all, during the study period (p=0.00). CONCLUSION: The administration of rhGH in long term resulted in the improvement in K-MBI, and subjectively less tiredness during the injection period. Korean Academy of Rehabilitation Medicine 2012-08 2012-08-27 /pmc/articles/PMC3438410/ /pubmed/22977769 http://dx.doi.org/10.5535/arm.2012.36.4.447 Text en Copyright © 2012 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Junyoung Park, Kicheol Lee, Hakil Kim, MinYoung The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial |
title | The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial |
title_full | The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial |
title_fullStr | The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial |
title_full_unstemmed | The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial |
title_short | The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial |
title_sort | effect of recombinant human growth hormone therapy in patients with completed stroke: a pilot trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438410/ https://www.ncbi.nlm.nih.gov/pubmed/22977769 http://dx.doi.org/10.5535/arm.2012.36.4.447 |
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