Cargando…

Role of Inflammation in Endophthalmitis

Inflammation originating from infection of the vitreous cavity is called endophthalmitis. Attention has been focused on the epidemiologic, microbiologic reports, and treatment options; unfortunately, the role of the host immune reaction in the visual function damage is still not well understood. End...

Descripción completa

Detalles Bibliográficos
Autores principales: Vallejo-Garcia, J. L., Asencio-Duran, M., Pastora-Salvador, N., Vinciguerra, P., Romano, M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438776/
https://www.ncbi.nlm.nih.gov/pubmed/22973073
http://dx.doi.org/10.1155/2012/196094
_version_ 1782242931786121216
author Vallejo-Garcia, J. L.
Asencio-Duran, M.
Pastora-Salvador, N.
Vinciguerra, P.
Romano, M. R.
author_facet Vallejo-Garcia, J. L.
Asencio-Duran, M.
Pastora-Salvador, N.
Vinciguerra, P.
Romano, M. R.
author_sort Vallejo-Garcia, J. L.
collection PubMed
description Inflammation originating from infection of the vitreous cavity is called endophthalmitis. Attention has been focused on the epidemiologic, microbiologic reports, and treatment options; unfortunately, the role of the host immune reaction in the visual function damage is still not well understood. Endophthalmitis occurs most frequently after cataract surgery. In this paper we review the published literature regarding inflammatory mediators and apoptosis during the course of endophthalmitis. Toll-like receptors, cytokines, high-mobility group box 1 proteins, aB-crystallin and apoptosis have been studied during clinical and experimental cases of endophthalmitis. Further understanding of the host-immune reaction to vitreous infection is essential for the development of new therapies. The use of intravitreal antibiotics and corticosteroids, vitrectomy and systemic antibiotics for the preservation of visual function is still discouraging.
format Online
Article
Text
id pubmed-3438776
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34387762012-09-12 Role of Inflammation in Endophthalmitis Vallejo-Garcia, J. L. Asencio-Duran, M. Pastora-Salvador, N. Vinciguerra, P. Romano, M. R. Mediators Inflamm Review Article Inflammation originating from infection of the vitreous cavity is called endophthalmitis. Attention has been focused on the epidemiologic, microbiologic reports, and treatment options; unfortunately, the role of the host immune reaction in the visual function damage is still not well understood. Endophthalmitis occurs most frequently after cataract surgery. In this paper we review the published literature regarding inflammatory mediators and apoptosis during the course of endophthalmitis. Toll-like receptors, cytokines, high-mobility group box 1 proteins, aB-crystallin and apoptosis have been studied during clinical and experimental cases of endophthalmitis. Further understanding of the host-immune reaction to vitreous infection is essential for the development of new therapies. The use of intravitreal antibiotics and corticosteroids, vitrectomy and systemic antibiotics for the preservation of visual function is still discouraging. Hindawi Publishing Corporation 2012 2012-09-02 /pmc/articles/PMC3438776/ /pubmed/22973073 http://dx.doi.org/10.1155/2012/196094 Text en Copyright © 2012 J. L. Vallejo-Garcia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vallejo-Garcia, J. L.
Asencio-Duran, M.
Pastora-Salvador, N.
Vinciguerra, P.
Romano, M. R.
Role of Inflammation in Endophthalmitis
title Role of Inflammation in Endophthalmitis
title_full Role of Inflammation in Endophthalmitis
title_fullStr Role of Inflammation in Endophthalmitis
title_full_unstemmed Role of Inflammation in Endophthalmitis
title_short Role of Inflammation in Endophthalmitis
title_sort role of inflammation in endophthalmitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438776/
https://www.ncbi.nlm.nih.gov/pubmed/22973073
http://dx.doi.org/10.1155/2012/196094
work_keys_str_mv AT vallejogarciajl roleofinflammationinendophthalmitis
AT asencioduranm roleofinflammationinendophthalmitis
AT pastorasalvadorn roleofinflammationinendophthalmitis
AT vinciguerrap roleofinflammationinendophthalmitis
AT romanomr roleofinflammationinendophthalmitis