SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions

Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; high...

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Detalles Bibliográficos
Autores principales: Euskirchen, Ghia, Auerbach, Raymond K., Snyder, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438922/
https://www.ncbi.nlm.nih.gov/pubmed/22952240
http://dx.doi.org/10.1074/jbc.R111.309302
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author Euskirchen, Ghia
Auerbach, Raymond K.
Snyder, Michael
author_facet Euskirchen, Ghia
Auerbach, Raymond K.
Snyder, Michael
author_sort Euskirchen, Ghia
collection PubMed
description Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including cancer and viral infections. These studies have greatly increased our understanding of complex nuclear processes.
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spelling pubmed-34389222012-09-13 SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions Euskirchen, Ghia Auerbach, Raymond K. Snyder, Michael J Biol Chem Minireviews Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including cancer and viral infections. These studies have greatly increased our understanding of complex nuclear processes. American Society for Biochemistry and Molecular Biology 2012-09-07 2012-09-05 /pmc/articles/PMC3438922/ /pubmed/22952240 http://dx.doi.org/10.1074/jbc.R111.309302 Text en © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Author's Choice—Final version full access. Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) applies to Author Choice Articles
spellingShingle Minireviews
Euskirchen, Ghia
Auerbach, Raymond K.
Snyder, Michael
SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions
title SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions
title_full SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions
title_fullStr SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions
title_full_unstemmed SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions
title_short SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions
title_sort swi/snf chromatin-remodeling factors: multiscale analyses and diverse functions
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438922/
https://www.ncbi.nlm.nih.gov/pubmed/22952240
http://dx.doi.org/10.1074/jbc.R111.309302
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