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A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations
BACKGROUND: Eukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex (ORC). ORC binds to specific origins of replica...
Autores principales: | Gidvani, Rohan D, Sudmant, Peter, Li, Grace, DaSilva, Lance F, McConkey, Brendan J, Duncker, Bernard P, Ingalls, Brian P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439281/ https://www.ncbi.nlm.nih.gov/pubmed/22738223 http://dx.doi.org/10.1186/1752-0509-6-78 |
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