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Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

BACKGROUND: We previously established a three-dimensional (3-D) colonic crypt model using HKe3 cells which are human colorectal cancer (CRC) HCT116 cells with a disruption in oncogenic KRAS, and revealed the crucial roles of oncogenic KRAS both in inhibition of apoptosis and in disruption of cell po...

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Detalles Bibliográficos
Autores principales:	Tsunoda, Toshiyuki, Ota, Takeharu, Fujimoto, Takahiro, Doi, Keiko, Tanaka, Yoko, Yoshida, Yasuhiro, Ogawa, Masahiro, Matsuzaki, Hiroshi, Hamabashiri, Masato, Tyson, Darren R, Kuroki, Masahide, Miyamoto, Shingo, Shirasawa, Senji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439292/ https://www.ncbi.nlm.nih.gov/pubmed/22830422 http://dx.doi.org/10.1186/1476-4598-11-46

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