Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors

A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90. We have determined the structure of the human Hsp90α N-terminal domain in complex with a series of 5-aryl-4-(5-substituted-2-...

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Detalles Bibliográficos
Autores principales: Sharp, Swee Y., Roe, S. Mark, Kazlauskas, Egidijus, Čikotienė, Inga, Workman, Paul, Matulis, Daumantas, Prodromou, Chrisostomos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439374/
https://www.ncbi.nlm.nih.gov/pubmed/22984537
http://dx.doi.org/10.1371/journal.pone.0044642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439374/
https://www.ncbi.nlm.nih.gov/pubmed/22984537
http://dx.doi.org/10.1371/journal.pone.0044642

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