Radiosynthesis of [(11)C]SNAP-7941—the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1)

The melanin concentrating hormone (MCH) system is a new target to treat human disorders. Our aim was the preparation of the first PET-tracer for the MCHR1. [(11)C]SNAP-7941 is a carbon-11 labeled analog of the published MCHR1 antagonist SNAP-7941. The optimum reaction conditions were 2 min reaction...

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Detalles Bibliográficos
Autores principales: Philippe, C., Schirmer, E., Mitterhauser, M., Shanab, K., Lanzenberger, R., Karanikas, G., Spreitzer, H., Viernstein, H., Wadsak, W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439630/
https://www.ncbi.nlm.nih.gov/pubmed/22858577
http://dx.doi.org/10.1016/j.apradiso.2012.07.010
Descripción
Sumario:The melanin concentrating hormone (MCH) system is a new target to treat human disorders. Our aim was the preparation of the first PET-tracer for the MCHR1. [(11)C]SNAP-7941 is a carbon-11 labeled analog of the published MCHR1 antagonist SNAP-7941. The optimum reaction conditions were 2 min reaction time, ≤25 °C reaction temperature, and 2 mg/mL precursor (SNAP-acid) in acetonitrile, using [(11)C]CH(3)OTf as methylation agent. [(11)C]SNAP-7941 was prepared in a reliable and feasible manner with high radiochemical yields (2.9±1.6 GBq; 11.5±6.4% EOB, n=15).

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