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PNET of kidney: Report of four cases

Primitive neuroectodermal tumor (PNET) of kidney is a rare tumor of kidney with only a few published reports. We report here four cases of PNET of kidney in the age group between 30 and 50 years who had complaints of vague pain and lump in loin. Hematuria was present in one case. Imaging of all case...

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Autores principales: Mandal, Palash Kumar, Mukherjee, Supti, Roy, Sravasti, Bhattacharyya, Nirmal Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439791/
https://www.ncbi.nlm.nih.gov/pubmed/22988357
http://dx.doi.org/10.4103/0971-5851.99754
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author Mandal, Palash Kumar
Mukherjee, Supti
Roy, Sravasti
Bhattacharyya, Nirmal Kumar
author_facet Mandal, Palash Kumar
Mukherjee, Supti
Roy, Sravasti
Bhattacharyya, Nirmal Kumar
author_sort Mandal, Palash Kumar
collection PubMed
description Primitive neuroectodermal tumor (PNET) of kidney is a rare tumor of kidney with only a few published reports. We report here four cases of PNET of kidney in the age group between 30 and 50 years who had complaints of vague pain and lump in loin. Hematuria was present in one case. Imaging of all cases revealed renal mass. The pathologic findings were consistent with PNET in all cases–confirmed by immunohistochemistry with diffuse membrane positivity of tumor cells of CD99. We could not do fluorescent in situ hybridization to demonstrate EWS-FLI-1 gene fusion. Each case was in the advanced stage. However, after giving postoperative radiotherapy and chemotherapy patients are still alive. Reporting of these cases are important as we got them in a short span of 3 years. In view of its poor prognosis, aggressive nature and different therapeutic approach– renal PNET should be differentiated from other small blue round cell tumors like neuroblastoma, rhabdoid tumor of kidney, nephroblastoma, small cell carcinoma, synovial sarcoma (monophasic, poorly differentiated) and non-Hodgkin lymphoma (NHL) by immunohistochemistry, cytogenetic, and molecular genetics study to see the different gene rearrangements in NHL and 3p deletion in small cell carcinoma.
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spelling pubmed-34397912012-09-17 PNET of kidney: Report of four cases Mandal, Palash Kumar Mukherjee, Supti Roy, Sravasti Bhattacharyya, Nirmal Kumar Indian J Med Paediatr Oncol Case Report Primitive neuroectodermal tumor (PNET) of kidney is a rare tumor of kidney with only a few published reports. We report here four cases of PNET of kidney in the age group between 30 and 50 years who had complaints of vague pain and lump in loin. Hematuria was present in one case. Imaging of all cases revealed renal mass. The pathologic findings were consistent with PNET in all cases–confirmed by immunohistochemistry with diffuse membrane positivity of tumor cells of CD99. We could not do fluorescent in situ hybridization to demonstrate EWS-FLI-1 gene fusion. Each case was in the advanced stage. However, after giving postoperative radiotherapy and chemotherapy patients are still alive. Reporting of these cases are important as we got them in a short span of 3 years. In view of its poor prognosis, aggressive nature and different therapeutic approach– renal PNET should be differentiated from other small blue round cell tumors like neuroblastoma, rhabdoid tumor of kidney, nephroblastoma, small cell carcinoma, synovial sarcoma (monophasic, poorly differentiated) and non-Hodgkin lymphoma (NHL) by immunohistochemistry, cytogenetic, and molecular genetics study to see the different gene rearrangements in NHL and 3p deletion in small cell carcinoma. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3439791/ /pubmed/22988357 http://dx.doi.org/10.4103/0971-5851.99754 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mandal, Palash Kumar
Mukherjee, Supti
Roy, Sravasti
Bhattacharyya, Nirmal Kumar
PNET of kidney: Report of four cases
title PNET of kidney: Report of four cases
title_full PNET of kidney: Report of four cases
title_fullStr PNET of kidney: Report of four cases
title_full_unstemmed PNET of kidney: Report of four cases
title_short PNET of kidney: Report of four cases
title_sort pnet of kidney: report of four cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439791/
https://www.ncbi.nlm.nih.gov/pubmed/22988357
http://dx.doi.org/10.4103/0971-5851.99754
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