Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking

Most cystic fibrosis is caused by mutations in CFTR that prevent its trafficking from the ER to the plasma membrane and is associated with exaggerated inflammation, altered metabolism, and diminished responses to oxidative stress. PARP-1 is activated by oxidative stress and causes energy depletion a...

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Detalles Bibliográficos
Autores principales: Anjos, Suzana M., Robert, Renaud, Waller, Daniel, Zhang, Dong Lei, Balghi, Haouaria, Sampson, Heidi M., Ciciriello, Fabiana, Lesimple, Pierre, Carlile, Graeme W., Goepp, Julie, Liao, Jie, Ferraro, Pasquale, Phillipe, Romeo, Dantzer, Françoise, Hanrahan, John W., Thomas, David Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439826/
https://www.ncbi.nlm.nih.gov/pubmed/22988441
http://dx.doi.org/10.3389/fphar.2012.00165

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