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Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor

Protein biosynthesis requires aminoacyl-transfer RNA (tRNA) synthetases to provide aminoacyl-tRNA substrates for the ribosome. Most bacteria and all archaea lack a glutaminyl-tRNA synthetase (GlnRS); instead, Gln-tRNA(Gln) is produced via an indirect pathway: a glutamyl-tRNA synthetase (GluRS) first...

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Detalles Bibliográficos
Autores principales:	Guo, Li-Tao, Helgadóttir, Sunna, Söll, Dieter, Ling, Jiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439900/ https://www.ncbi.nlm.nih.gov/pubmed/22661575 http://dx.doi.org/10.1093/nar/gks507

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