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Computational mapping reveals dramatic effect of Hoogsteen breathing on duplex DNA reactivity with formaldehyde

Formaldehyde has long been recognized as a hazardous environmental agent highly reactive with DNA. Recently, it has been realized that due to the activity of histone demethylation enzymes within the cell nucleus, formaldehyde is produced endogenously, in direct vicinity of genomic DNA. Should it lea...

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Detalles Bibliográficos
Autores principales:	Bohnuud, Tanggis, Beglov, Dmitri, Ngan, Chi Ho, Zerbe, Brandon, Hall, David R., Brenke, Ryan, Vajda, Sandor, Frank-Kamenetskii, Maxim D., Kozakov, Dima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439909/ https://www.ncbi.nlm.nih.gov/pubmed/22705795 http://dx.doi.org/10.1093/nar/gks519

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