Cargando…

Reduced PKC α Activity Induces Senescent Phenotype in Erythrocytes

The molecular mechanism mediating expression of senescent cell antigen-aggregated or cleaved band 3 and externalized phosphatidylserine (PS) on the surface of aged erythrocytes and their premature expression in certain anemias is not completely elucidated. The erythrocytes with these surface modific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Govekar, Rukmini B., Kawle, Poonam D., Advani, Suresh H., Zingde, Surekha M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439938/ https://www.ncbi.nlm.nih.gov/pubmed/22988493 http://dx.doi.org/10.1155/2012/168050

Ejemplares similares

Eryptotic Phenotype in Chronic Myeloid Leukemia: Contribution of Neutrophilic Cathepsin G
por: Govekar, Rukmini, et al.
Publicado: (2012)

Database and interaction network of genes involved in oral cancer: Version II
por: Gadewal, Nikhil Sureshkumar, et al.
Publicado: (2011)

PKCη promotes senescence induced by oxidative stress and chemotherapy
por: Zurgil, U, et al.
Publicado: (2014)

PKCα and PKCδ: Friends and Rivals
por: Black, Jennifer D., et al.
Publicado: (2022)

PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma
por: Restall, Ian J, et al.
Publicado: (2015)

Increase in PKCα Activity during Heart Failure Despite the Stimulation of PKCα Braking Mechanism
por: Aslam, Naveed
Publicado: (2020)

Clinical biomarker discovery by SWATH-MS based label-free quantitative proteomics: impact of criteria for identification of differentiators and data normalization method
por: Narasimhan, Mythreyi, et al.
Publicado: (2019)

Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes
por: Seki, Momoko, et al.
Publicado: (2020)

Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes
por: Du, Ying, et al.
Publicado: (2018)

Src, PKCα, and PKCδ are required for αvβ3 integrin-mediated metastatic melanoma invasion
por: Putnam, Andrew J, et al.
Publicado: (2009)

Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity
por: Galea, Gabriel L., et al.
Publicado: (2014)

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2020)

PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription
por: Christina, Lutz-Nicoladoni, et al.
Publicado: (2013)

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
por: Shrestha, Niraj, et al.
Publicado: (2023)

Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-α, and JNK
por: Lew, Bark-Lynn, et al.
Publicado: (2006)

DNA Fingerprint Analysis of Raman Spectra Captures Global Genomic Alterations in Imatinib-Resistant Chronic Myeloid Leukemia: A Potential Single Assay for Screening Imatinib Resistance
por: Mojidra, Rahul, et al.
Publicado: (2021)

Inhibition of PKC‐δ reduce rhabdomyolysis‐induced acute kidney injury
por: Wu, Dengke, et al.
Publicado: (2022)

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation
por: Halder, Kuntal, et al.
Publicado: (2014)

Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
por: Yin, Kelvin, et al.
Publicado: (2022)

PKCα diffusion and translocation are independent of an intact cytoskeleton
por: Hui, Xin, et al.
Publicado: (2017)

Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα
por: Rosato, Benedetta, et al.
Publicado: (2018)

Nox‐4 deletion reduces oxidative stress and injury by PKC‐α‐associated mechanisms in diabetic nephropathy
por: Thallas‐Bonke, Vicki, et al.
Publicado: (2014)

The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor‐1α
por: Wu, Selwin K., et al.
Publicado: (2023)

miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis
por: Yin, Ruili, et al.
Publicado: (2016)

Coronavirus disease 2019 (COVID-19), human erythrocytes and the PKC-alpha/-beta inhibitor chelerythrine –possible therapeutic implication
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2020)

Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer
por: Dupasquier, Sébastien, et al.
Publicado: (2019)

Erratum to: The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor‐1α
Publicado: (2023)

PKCα expression is a marker for breast cancer aggressiveness
por: Lønne, Gry Kalstad, et al.
Publicado: (2010)

Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome
por: Chaudhary, Manoj Kumar, et al.
Publicado: (2018)

PKC-δ mediates interferon-α-induced apoptosis through c-Jun NH(2)-terminal kinase activation
por: Yanase, Noriko, et al.
Publicado: (2012)

Sequential Activation of Classic PKC and Estrogen Receptor α Is Involved in Estradiol 17ß-D-Glucuronide-Induced Cholestasis
por: Barosso, Ismael R., et al.
Publicado: (2012)

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms
por: Wong, Vincent Kam Wai, et al.
Publicado: (2017)

PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways
por: Kveiborg, Marie, et al.
Publicado: (2011)

Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
por: Kim, Jin-Man, et al.
Publicado: (2018)

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts
por: Guan, Yiting, et al.
Publicado: (2020)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model
por: Kim, Jeewon, et al.
Publicado: (2010)

Cell senescence, the senescence-associated secretory phenotype, and cancers
por: Langhi Prata, Larissa G. P., et al.
Publicado: (2023)

The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation
por: Huna, Anda, et al.
Publicado: (2023)

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype
por: Gardner, Sarah E., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p0preope7rpk640v1a5doui5tb