Cargando…
Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disorder characterized by differences in autoantibody profiles, serum cytokines, and clinical manifestations. We have previously conducted a case-case genome-wide association study (GWAS) of SLE patients to detect associations w...
Autores principales: | Koldobskaya, Yelena, Ko, Kichul, Kumar, Akaash A., Agik, Sandra, Arrington, Jasmine, Kariuki, Silvia N., Franek, Beverly S., Kumabe, Marissa, Utset, Tammy O., Jolly, Meenakshi, Skol, Andrew D., Niewold, Timothy B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439981/ https://www.ncbi.nlm.nih.gov/pubmed/22988468 http://dx.doi.org/10.1155/2012/682018 |
Ejemplares similares
-
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
por: Kariuki, Silvia N, et al.
Publicado: (2010) -
Osteopontin Alleles Are Associated with Clinical Characteristics in Systemic Lupus Erythematosus
por: Trivedi, Tarak, et al.
Publicado: (2011) -
Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients
por: Kariuki, Silvia N., et al.
Publicado: (2010) -
Genetic Variation near IRF8 is Associated with Serologic and Cytokine Profiles in Systemic Lupus Erythematosus and Multiple Sclerosis
por: Chrabot, Beverly S., et al.
Publicado: (2013) -
Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients
por: Ko, Kichul, et al.
Publicado: (2013)