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Alkaloids Isolated from Natural Herbs as the Anticancer Agents

Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, hav...

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Detalles Bibliográficos
Autores principales: Lu, Jin-Jian, Bao, Jiao-Lin, Chen, Xiu-Ping, Huang, Min, Wang, Yi-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440018/
https://www.ncbi.nlm.nih.gov/pubmed/22988474
http://dx.doi.org/10.1155/2012/485042
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author Lu, Jin-Jian
Bao, Jiao-Lin
Chen, Xiu-Ping
Huang, Min
Wang, Yi-Tao
author_facet Lu, Jin-Jian
Bao, Jiao-Lin
Chen, Xiu-Ping
Huang, Min
Wang, Yi-Tao
author_sort Lu, Jin-Jian
collection PubMed
description Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs. This paper focuses on the naturally derived alkaloids with prospective anticancer properties, such as berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the mechanisms of action of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made.
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spelling pubmed-34400182012-09-17 Alkaloids Isolated from Natural Herbs as the Anticancer Agents Lu, Jin-Jian Bao, Jiao-Lin Chen, Xiu-Ping Huang, Min Wang, Yi-Tao Evid Based Complement Alternat Med Review Article Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs. This paper focuses on the naturally derived alkaloids with prospective anticancer properties, such as berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the mechanisms of action of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made. Hindawi Publishing Corporation 2012 2012-09-04 /pmc/articles/PMC3440018/ /pubmed/22988474 http://dx.doi.org/10.1155/2012/485042 Text en Copyright © 2012 Jin-Jian Lu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lu, Jin-Jian
Bao, Jiao-Lin
Chen, Xiu-Ping
Huang, Min
Wang, Yi-Tao
Alkaloids Isolated from Natural Herbs as the Anticancer Agents
title Alkaloids Isolated from Natural Herbs as the Anticancer Agents
title_full Alkaloids Isolated from Natural Herbs as the Anticancer Agents
title_fullStr Alkaloids Isolated from Natural Herbs as the Anticancer Agents
title_full_unstemmed Alkaloids Isolated from Natural Herbs as the Anticancer Agents
title_short Alkaloids Isolated from Natural Herbs as the Anticancer Agents
title_sort alkaloids isolated from natural herbs as the anticancer agents
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440018/
https://www.ncbi.nlm.nih.gov/pubmed/22988474
http://dx.doi.org/10.1155/2012/485042
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