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Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort
Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior. Objective: We examined the association between...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440080/ https://www.ncbi.nlm.nih.gov/pubmed/22543054 http://dx.doi.org/10.1289/ehp.1104492 |
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author | Perera, Frederica Vishnevetsky, Julia Herbstman, Julie B Calafat, Antonia M Xiong, Wei Rauh, Virginia Wang, Shuang |
author_facet | Perera, Frederica Vishnevetsky, Julia Herbstman, Julie B Calafat, Antonia M Xiong, Wei Rauh, Virginia Wang, Shuang |
author_sort | Perera, Frederica |
collection | PubMed |
description | Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior. Objective: We examined the association between prenatal BPA exposure and child behavior, adjusting for postnatal BPA exposure and hypothesizing sex-specific effects. Methods: We followed African-American and Dominican women and their children from pregnancy to child’s age 5 years, collecting spot urine samples from the mothers during pregnancy (34 weeks on average) and from children between 3 and 4 years of age to estimate BPA exposure. We assessed child behavior between 3 and 5 years of age using the Child Behavior Checklist (CBCL) and used generalized linear models to test the association between BPA exposure and child behavior, adjusting for potential confounders. Results: The analysis was conducted on 198 children (87 boys and 111 girls). Among boys, high prenatal BPA exposure (highest quartile vs. the lowest three quartiles) was associated with significantly higher CBCL scores (more problems) on Emotionally Reactive [1.62 times greater; 95% confidence interval (CI): 1.13, 2.32] and Aggressive Behavior syndromes (1.29 times greater; 95% CI: 1.09, 1.53). Among girls, higher exposure was associated with lower scores on all syndromes, reaching statistical significance for Anxious/Depressed (0.75 times as high; 95% CI: 0.57, 0.99) and Aggressive Behavior (0.82 times as high; 95% CI: 0.70, 0.97). Conclusion: These results suggest that prenatal exposure to BPA may affect child behavior, and differently among boys and girls. |
format | Online Article Text |
id | pubmed-3440080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-34400802012-09-12 Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort Perera, Frederica Vishnevetsky, Julia Herbstman, Julie B Calafat, Antonia M Xiong, Wei Rauh, Virginia Wang, Shuang Environ Health Perspect Research Background: Experimental laboratory evidence suggests that bisphenol A (BPA), an endocrine disruptor, is a neurodevelopmental toxicant. However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior. Objective: We examined the association between prenatal BPA exposure and child behavior, adjusting for postnatal BPA exposure and hypothesizing sex-specific effects. Methods: We followed African-American and Dominican women and their children from pregnancy to child’s age 5 years, collecting spot urine samples from the mothers during pregnancy (34 weeks on average) and from children between 3 and 4 years of age to estimate BPA exposure. We assessed child behavior between 3 and 5 years of age using the Child Behavior Checklist (CBCL) and used generalized linear models to test the association between BPA exposure and child behavior, adjusting for potential confounders. Results: The analysis was conducted on 198 children (87 boys and 111 girls). Among boys, high prenatal BPA exposure (highest quartile vs. the lowest three quartiles) was associated with significantly higher CBCL scores (more problems) on Emotionally Reactive [1.62 times greater; 95% confidence interval (CI): 1.13, 2.32] and Aggressive Behavior syndromes (1.29 times greater; 95% CI: 1.09, 1.53). Among girls, higher exposure was associated with lower scores on all syndromes, reaching statistical significance for Anxious/Depressed (0.75 times as high; 95% CI: 0.57, 0.99) and Aggressive Behavior (0.82 times as high; 95% CI: 0.70, 0.97). Conclusion: These results suggest that prenatal exposure to BPA may affect child behavior, and differently among boys and girls. National Institute of Environmental Health Sciences 2012-04-27 2012-08 /pmc/articles/PMC3440080/ /pubmed/22543054 http://dx.doi.org/10.1289/ehp.1104492 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Perera, Frederica Vishnevetsky, Julia Herbstman, Julie B Calafat, Antonia M Xiong, Wei Rauh, Virginia Wang, Shuang Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort |
title | Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort |
title_full | Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort |
title_fullStr | Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort |
title_full_unstemmed | Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort |
title_short | Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort |
title_sort | prenatal bisphenol a exposure and child behavior in an inner-city cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440080/ https://www.ncbi.nlm.nih.gov/pubmed/22543054 http://dx.doi.org/10.1289/ehp.1104492 |
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