Cargando…

Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008

Background: Previous studies have shown that women have higher urinary concentrations of several phthalate metabolites than do men, possibly because of a higher use of personal care products. Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related ris...

Descripción completa

Detalles Bibliográficos
Autores principales: James-Todd, Tamarra, Stahlhut, Richard, Meeker, John D., Powell, Sheena-Gail, Hauser, Russ, Huang, Tianyi, Rich-Edwards, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440117/
https://www.ncbi.nlm.nih.gov/pubmed/22796563
http://dx.doi.org/10.1289/ehp.1104717
_version_ 1782243122082742272
author James-Todd, Tamarra
Stahlhut, Richard
Meeker, John D.
Powell, Sheena-Gail
Hauser, Russ
Huang, Tianyi
Rich-Edwards, Janet
author_facet James-Todd, Tamarra
Stahlhut, Richard
Meeker, John D.
Powell, Sheena-Gail
Hauser, Russ
Huang, Tianyi
Rich-Edwards, Janet
author_sort James-Todd, Tamarra
collection PubMed
description Background: Previous studies have shown that women have higher urinary concentrations of several phthalate metabolites than do men, possibly because of a higher use of personal care products. Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors among women. Objective: We explored the association between urinary phthalate metabolite concentrations and diabetes among women who participated in a cross-sectional study. Methods: We used urinary concentrations of phthalate metabolites, analyzed by the Centers for Disease Control and Prevention, and self-reported diabetes of 2,350 women between 20 and 79 years of age who participated in the NHANES (2001–2008). We used multiple logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) and adjusted for urinary creatinine, sociodemographic characteristics, dietary factors, and body size. A secondary analysis was conducted for women who did not have diabetes to evaluate the association between phthalate metabolite concentrations and fasting blood glucose (FBG), homeostasis model assessment–estimated insulin resistance, and glycosylated hemoglobin A1c. Results: After adjusting for potential confounders, women with higher levels of mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono-(3-carboxypropyl) phthalate (MCPP), and three di-(2-ethylhexyl) phthalate metabolites (ΣDEHP) had an increased odds of diabetes compared with women with the lowest levels of these phthalates. Women in the highest quartile for MBzP and MiBP had almost twice the odds of diabetes [OR = 1.96 (95% CI: 1.11, 3.47) and OR = 1.95 (95% CI: 0.99, 3.85), respectively] compared with women in the lowest quartile. Nonmonotonic, positive associations were found for MnBP and ΣDEHP, whereas MCPP appeared to have a threshold effect. Certain phthalate metabolites were positively associated with FBG and insulin resistance. Discussion: Urinary levels of several phthalates were associated with prevalent diabetes. Future prospective studies are needed to further explore these associations to determine whether phthalate exposure can alter glucose metabolism and increase the risk of insulin resistance and diabetes.
format Online
Article
Text
id pubmed-3440117
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher National Institute of Environmental Health Sciences
record_format MEDLINE/PubMed
spelling pubmed-34401172012-10-04 Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008 James-Todd, Tamarra Stahlhut, Richard Meeker, John D. Powell, Sheena-Gail Hauser, Russ Huang, Tianyi Rich-Edwards, Janet Environ Health Perspect Research Background: Previous studies have shown that women have higher urinary concentrations of several phthalate metabolites than do men, possibly because of a higher use of personal care products. Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors among women. Objective: We explored the association between urinary phthalate metabolite concentrations and diabetes among women who participated in a cross-sectional study. Methods: We used urinary concentrations of phthalate metabolites, analyzed by the Centers for Disease Control and Prevention, and self-reported diabetes of 2,350 women between 20 and 79 years of age who participated in the NHANES (2001–2008). We used multiple logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) and adjusted for urinary creatinine, sociodemographic characteristics, dietary factors, and body size. A secondary analysis was conducted for women who did not have diabetes to evaluate the association between phthalate metabolite concentrations and fasting blood glucose (FBG), homeostasis model assessment–estimated insulin resistance, and glycosylated hemoglobin A1c. Results: After adjusting for potential confounders, women with higher levels of mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono-(3-carboxypropyl) phthalate (MCPP), and three di-(2-ethylhexyl) phthalate metabolites (ΣDEHP) had an increased odds of diabetes compared with women with the lowest levels of these phthalates. Women in the highest quartile for MBzP and MiBP had almost twice the odds of diabetes [OR = 1.96 (95% CI: 1.11, 3.47) and OR = 1.95 (95% CI: 0.99, 3.85), respectively] compared with women in the lowest quartile. Nonmonotonic, positive associations were found for MnBP and ΣDEHP, whereas MCPP appeared to have a threshold effect. Certain phthalate metabolites were positively associated with FBG and insulin resistance. Discussion: Urinary levels of several phthalates were associated with prevalent diabetes. Future prospective studies are needed to further explore these associations to determine whether phthalate exposure can alter glucose metabolism and increase the risk of insulin resistance and diabetes. National Institute of Environmental Health Sciences 2012-07-13 2012-09 /pmc/articles/PMC3440117/ /pubmed/22796563 http://dx.doi.org/10.1289/ehp.1104717 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
James-Todd, Tamarra
Stahlhut, Richard
Meeker, John D.
Powell, Sheena-Gail
Hauser, Russ
Huang, Tianyi
Rich-Edwards, Janet
Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008
title Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008
title_full Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008
title_fullStr Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008
title_full_unstemmed Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008
title_short Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001–2008
title_sort urinary phthalate metabolite concentrations and diabetes among women in the national health and nutrition examination survey (nhanes) 2001–2008
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440117/
https://www.ncbi.nlm.nih.gov/pubmed/22796563
http://dx.doi.org/10.1289/ehp.1104717
work_keys_str_mv AT jamestoddtamarra urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008
AT stahlhutrichard urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008
AT meekerjohnd urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008
AT powellsheenagail urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008
AT hauserruss urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008
AT huangtianyi urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008
AT richedwardsjanet urinaryphthalatemetaboliteconcentrationsanddiabetesamongwomeninthenationalhealthandnutritionexaminationsurveynhanes20012008