Distinct Annular Oligomers Captured along the Assembly and Disassembly Pathways of Transthyretin Amyloid Protofibrils

BACKGROUND: Defects in protein folding may lead to severe degenerative diseases characterized by the appearance of amyloid fibril deposits. Cytotoxicity in amyloidoses has been linked to poration of the cell membrane that may involve interactions with amyloid intermediates of annular shape. Although...

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Detalles Bibliográficos
Autores principales: Pires, Ricardo H., Karsai, Árpád, Saraiva, Maria J., Damas, Ana M., Kellermayer, Miklós S. Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440338/
https://www.ncbi.nlm.nih.gov/pubmed/22984597
http://dx.doi.org/10.1371/journal.pone.0044992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440338/
https://www.ncbi.nlm.nih.gov/pubmed/22984597
http://dx.doi.org/10.1371/journal.pone.0044992

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