Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2

Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC...

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Autores principales: Hoxha, Eneda, Lambers, Erin, Wasserstrom, John A., Mackie, Alexander, Ramirez, Veronica, Abramova, Tatiana, Verma, Suresh K., Krishnamurthy, Prasanna, Kishore, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440419/
https://www.ncbi.nlm.nih.gov/pubmed/22984607
http://dx.doi.org/10.1371/journal.pone.0045046
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author Hoxha, Eneda
Lambers, Erin
Wasserstrom, John A.
Mackie, Alexander
Ramirez, Veronica
Abramova, Tatiana
Verma, Suresh K.
Krishnamurthy, Prasanna
Kishore, Raj
author_facet Hoxha, Eneda
Lambers, Erin
Wasserstrom, John A.
Mackie, Alexander
Ramirez, Veronica
Abramova, Tatiana
Verma, Suresh K.
Krishnamurthy, Prasanna
Kishore, Raj
author_sort Hoxha, Eneda
collection PubMed
description Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.
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spelling pubmed-34404192012-09-14 Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2 Hoxha, Eneda Lambers, Erin Wasserstrom, John A. Mackie, Alexander Ramirez, Veronica Abramova, Tatiana Verma, Suresh K. Krishnamurthy, Prasanna Kishore, Raj PLoS One Research Article Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate. Public Library of Science 2012-09-12 /pmc/articles/PMC3440419/ /pubmed/22984607 http://dx.doi.org/10.1371/journal.pone.0045046 Text en © 2012 Hoxha et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hoxha, Eneda
Lambers, Erin
Wasserstrom, John A.
Mackie, Alexander
Ramirez, Veronica
Abramova, Tatiana
Verma, Suresh K.
Krishnamurthy, Prasanna
Kishore, Raj
Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
title Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
title_full Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
title_fullStr Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
title_full_unstemmed Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
title_short Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2
title_sort elucidation of a novel pathway through which hdac1 controls cardiomyocyte differentiation through expression of sox-17 and bmp2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440419/
https://www.ncbi.nlm.nih.gov/pubmed/22984607
http://dx.doi.org/10.1371/journal.pone.0045046
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