Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation

Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2 inhibits neutrophil elastase, thereby enhancing p...

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Detalles Bibliográficos
Autores principales: Morrison, Lesley S, Goundry, Amy, Faria, Marilia S, Tetley, Laurence, Eschenlauer, Sylvain C, Westrop, Gareth D, Dostalova, Anna, Volf, Petr, Coombs, Graham H, Lima, Ana Paula C A, Mottram, Jeremy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440592/
https://www.ncbi.nlm.nih.gov/pubmed/22486816
http://dx.doi.org/10.1111/j.1462-5822.2012.01798.x

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