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Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field
Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440595/ https://www.ncbi.nlm.nih.gov/pubmed/22583762 http://dx.doi.org/10.1111/j.1461-0248.2012.01791.x |
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author | Eizaguirre, Christophe Lenz, Tobias L Kalbe, Martin Milinski, Manfred |
author_facet | Eizaguirre, Christophe Lenz, Tobias L Kalbe, Martin Milinski, Manfred |
author_sort | Eizaguirre, Christophe |
collection | PubMed |
description | Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance of locally adapted MHC genotypes. |
format | Online Article Text |
id | pubmed-3440595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34405952012-09-13 Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field Eizaguirre, Christophe Lenz, Tobias L Kalbe, Martin Milinski, Manfred Ecol Lett Letters Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance of locally adapted MHC genotypes. Blackwell Publishing Ltd 2012-07 2012-05-15 /pmc/articles/PMC3440595/ /pubmed/22583762 http://dx.doi.org/10.1111/j.1461-0248.2012.01791.x Text en Copyright © 2012 Blackwell Publishing Ltd/CNRS http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Letters Eizaguirre, Christophe Lenz, Tobias L Kalbe, Martin Milinski, Manfred Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
title | Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
title_full | Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
title_fullStr | Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
title_full_unstemmed | Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
title_short | Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
title_sort | divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field |
topic | Letters |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440595/ https://www.ncbi.nlm.nih.gov/pubmed/22583762 http://dx.doi.org/10.1111/j.1461-0248.2012.01791.x |
work_keys_str_mv | AT eizaguirrechristophe divergentselectiononlocallyadaptedmajorhistocompatibilitycompleximmunegenesexperimentallyproveninthefield AT lenztobiasl divergentselectiononlocallyadaptedmajorhistocompatibilitycompleximmunegenesexperimentallyproveninthefield AT kalbemartin divergentselectiononlocallyadaptedmajorhistocompatibilitycompleximmunegenesexperimentallyproveninthefield AT milinskimanfred divergentselectiononlocallyadaptedmajorhistocompatibilitycompleximmunegenesexperimentallyproveninthefield |