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Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum

Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia...

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Detalles Bibliográficos
Autores principales: Vaquero, Jesús, Saldaña, Cristobal, Coca, Santiago, Zurita, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440858/
https://www.ncbi.nlm.nih.gov/pubmed/22988535
http://dx.doi.org/10.1155/2012/718651
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author Vaquero, Jesús
Saldaña, Cristobal
Coca, Santiago
Zurita, Mercedes
author_facet Vaquero, Jesús
Saldaña, Cristobal
Coca, Santiago
Zurita, Mercedes
author_sort Vaquero, Jesús
collection PubMed
description Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia. On CT-scan, an intraparenchymatous cerebellar tumor was disclosed. It was isodense, showing light enhancement after contrast administration. On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration. On T2-weighted MRI, the tumor was inhomogenously hyperintense. At surgery, a solid and hypervascularized tumor was completely removed. Two years after surgery, the patient is symptom-free. Pathological study showed coexistence of areas of pilocytic astrocytoma with areas in which small rounded oligodendrocyte-like cells (OLC), with strong synaptophysin expression were identified. These neurocytic areas showed an eosinophilic matrix forming microcysts, and cells with aspect of “floating neurons” were occasionally identified. A complex form variant of DNT was diagnosed. Our case suggests that in presence of a cerebellar tumor with features of pilocytic astrocytoma, the possibility of a complex form variant of DNT should be considered.
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spelling pubmed-34408582012-09-17 Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum Vaquero, Jesús Saldaña, Cristobal Coca, Santiago Zurita, Mercedes Case Rep Pathol Case Report Dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm with typical supratentorial location, but the possibility of these rare tumors can also be located in the posterior fossa must be taken into account. We report a 21-year-old woman that suffered gait instability, headache, and diplopia. On CT-scan, an intraparenchymatous cerebellar tumor was disclosed. It was isodense, showing light enhancement after contrast administration. On MRI (T1-weighted image) the tumor was isointense, showing inhomogeneous hyperintensity after-gadolinium administration. On T2-weighted MRI, the tumor was inhomogenously hyperintense. At surgery, a solid and hypervascularized tumor was completely removed. Two years after surgery, the patient is symptom-free. Pathological study showed coexistence of areas of pilocytic astrocytoma with areas in which small rounded oligodendrocyte-like cells (OLC), with strong synaptophysin expression were identified. These neurocytic areas showed an eosinophilic matrix forming microcysts, and cells with aspect of “floating neurons” were occasionally identified. A complex form variant of DNT was diagnosed. Our case suggests that in presence of a cerebellar tumor with features of pilocytic astrocytoma, the possibility of a complex form variant of DNT should be considered. Hindawi Publishing Corporation 2012 2012-09-05 /pmc/articles/PMC3440858/ /pubmed/22988535 http://dx.doi.org/10.1155/2012/718651 Text en Copyright © 2012 Jesús Vaquero et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vaquero, Jesús
Saldaña, Cristobal
Coca, Santiago
Zurita, Mercedes
Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
title Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
title_full Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
title_fullStr Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
title_full_unstemmed Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
title_short Complex Form Variant of Dysembryoplastic Neuroepithelial Tumor of the Cerebellum
title_sort complex form variant of dysembryoplastic neuroepithelial tumor of the cerebellum
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440858/
https://www.ncbi.nlm.nih.gov/pubmed/22988535
http://dx.doi.org/10.1155/2012/718651
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