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Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögre...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440923/ https://www.ncbi.nlm.nih.gov/pubmed/22988469 http://dx.doi.org/10.1155/2012/871401 |
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author | Himoto, Takashi Masaki, Tsutomu |
author_facet | Himoto, Takashi Masaki, Tsutomu |
author_sort | Himoto, Takashi |
collection | PubMed |
description | Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren's syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders. |
format | Online Article Text |
id | pubmed-3440923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34409232012-09-17 Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection Himoto, Takashi Masaki, Tsutomu Clin Dev Immunol Review Article Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren's syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders. Hindawi Publishing Corporation 2012 2012-09-05 /pmc/articles/PMC3440923/ /pubmed/22988469 http://dx.doi.org/10.1155/2012/871401 Text en Copyright © 2012 T. Himoto and T. Masaki. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Himoto, Takashi Masaki, Tsutomu Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection |
title | Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection |
title_full | Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection |
title_fullStr | Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection |
title_full_unstemmed | Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection |
title_short | Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection |
title_sort | extrahepatic manifestations and autoantibodies in patients with hepatitis c virus infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440923/ https://www.ncbi.nlm.nih.gov/pubmed/22988469 http://dx.doi.org/10.1155/2012/871401 |
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