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Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögre...

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Autores principales: Himoto, Takashi, Masaki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440923/
https://www.ncbi.nlm.nih.gov/pubmed/22988469
http://dx.doi.org/10.1155/2012/871401
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author Himoto, Takashi
Masaki, Tsutomu
author_facet Himoto, Takashi
Masaki, Tsutomu
author_sort Himoto, Takashi
collection PubMed
description Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren's syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders.
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spelling pubmed-34409232012-09-17 Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection Himoto, Takashi Masaki, Tsutomu Clin Dev Immunol Review Article Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren's syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders. Hindawi Publishing Corporation 2012 2012-09-05 /pmc/articles/PMC3440923/ /pubmed/22988469 http://dx.doi.org/10.1155/2012/871401 Text en Copyright © 2012 T. Himoto and T. Masaki. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Himoto, Takashi
Masaki, Tsutomu
Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
title Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
title_full Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
title_fullStr Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
title_full_unstemmed Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
title_short Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection
title_sort extrahepatic manifestations and autoantibodies in patients with hepatitis c virus infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440923/
https://www.ncbi.nlm.nih.gov/pubmed/22988469
http://dx.doi.org/10.1155/2012/871401
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