Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

[Image: see text] Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid and the endocannabinoids 2-arachidonoylglycerol (2-AG) and arachidonoylethanolamide (AEA). We recently reported that (R)-profens selectively inhibit endocannabinoid oxygenation but not arachidonic acid oxygenation. In this work,...

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Detalles Bibliográficos
Autores principales: Windsor, Matthew A., Hermanson, Daniel J., Kingsley, Philip J., Xu, Shu, Crews, Brenda C., Ho, Winnie, Keenan, Catherine M., Banerjee, Surajit, Sharkey, Keith A., Marnett, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441040/
https://www.ncbi.nlm.nih.gov/pubmed/22984634
http://dx.doi.org/10.1021/ml3001616

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