The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque

Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal mod...

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Detalles Bibliográficos
Autores principales: Zhang, Guangyin, Li, Ming, Li, Liangjun, Xu, Yingzhi, Li, Peng, Yang, Cui, Zhou, Yanan, Zhang, Junping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441062/
https://www.ncbi.nlm.nih.gov/pubmed/22988422
http://dx.doi.org/10.1155/2012/249129
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author Zhang, Guangyin
Li, Ming
Li, Liangjun
Xu, Yingzhi
Li, Peng
Yang, Cui
Zhou, Yanan
Zhang, Junping
author_facet Zhang, Guangyin
Li, Ming
Li, Liangjun
Xu, Yingzhi
Li, Peng
Yang, Cui
Zhou, Yanan
Zhang, Junping
author_sort Zhang, Guangyin
collection PubMed
description Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.
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spelling pubmed-34410622012-09-17 The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque Zhang, Guangyin Li, Ming Li, Liangjun Xu, Yingzhi Li, Peng Yang, Cui Zhou, Yanan Zhang, Junping J Biomed Biotechnol Research Article Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque. Hindawi Publishing Corporation 2012 2012-09-04 /pmc/articles/PMC3441062/ /pubmed/22988422 http://dx.doi.org/10.1155/2012/249129 Text en Copyright © 2012 Guangyin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Guangyin
Li, Ming
Li, Liangjun
Xu, Yingzhi
Li, Peng
Yang, Cui
Zhou, Yanan
Zhang, Junping
The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_full The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_fullStr The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_full_unstemmed The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_short The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_sort immunologic injury composite with balloon injury leads to dyslipidemia: a robust rabbit model of human atherosclerosis and vulnerable plaque
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441062/
https://www.ncbi.nlm.nih.gov/pubmed/22988422
http://dx.doi.org/10.1155/2012/249129
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