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It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug

“Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol” is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fu...

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Autores principales: Mesa-Arango, Ana C., Scorzoni, Liliana, Zaragoza, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441194/
https://www.ncbi.nlm.nih.gov/pubmed/23024638
http://dx.doi.org/10.3389/fmicb.2012.00286
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author Mesa-Arango, Ana C.
Scorzoni, Liliana
Zaragoza, Oscar
author_facet Mesa-Arango, Ana C.
Scorzoni, Liliana
Zaragoza, Oscar
author_sort Mesa-Arango, Ana C.
collection PubMed
description “Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol” is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells.
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spelling pubmed-34411942012-09-28 It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug Mesa-Arango, Ana C. Scorzoni, Liliana Zaragoza, Oscar Front Microbiol Microbiology “Amphotericin B acts through pore formation at the cell membrane after binding to ergosterol” is an accepted dogma about the action mechanism of this antifungal, and this sentence is widely found in the literature. But after 60 years of investigation, the action mechanism of Amphotericin B is not fully elucidated. Amphotericin B is a polyene substance that is one of the most effective drugs for the treatment of fungal and parasite infections. As stated above, the first mechanism of action described was pore formation after binding to the ergosterol present in the membrane. But it has also been demonstrated that AmB induces oxidative damage in the cells. Moreover, amphotericin B modulates the immune system, and this activity has been related to the protective effect of the molecule, but also to its toxicity in the host. This review tries to provide a general overview of the main aspects of this molecule, and highlight the multiple effects that this molecule has on both the fungal and host cells. Frontiers Media S.A. 2012-08-08 /pmc/articles/PMC3441194/ /pubmed/23024638 http://dx.doi.org/10.3389/fmicb.2012.00286 Text en Copyright © 2012 Mesa-Arango, Scorzoni and Zaragoza. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Microbiology
Mesa-Arango, Ana C.
Scorzoni, Liliana
Zaragoza, Oscar
It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
title It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
title_full It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
title_fullStr It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
title_full_unstemmed It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
title_short It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug
title_sort it only takes one to do many jobs: amphotericin b as antifungal and immunomodulatory drug
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441194/
https://www.ncbi.nlm.nih.gov/pubmed/23024638
http://dx.doi.org/10.3389/fmicb.2012.00286
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