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Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease
BACKGROUND: Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at different stages of disease. METHODS: Albumin was measured in cerebrospinal flu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441323/ https://www.ncbi.nlm.nih.gov/pubmed/22870899 http://dx.doi.org/10.1186/1742-2094-9-188 |
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author | Pisani, Valerio Stefani, Alessandro Pierantozzi, Mariangela Natoli, Silvia Stanzione, Paolo Franciotta, Diego Pisani, Antonio |
author_facet | Pisani, Valerio Stefani, Alessandro Pierantozzi, Mariangela Natoli, Silvia Stanzione, Paolo Franciotta, Diego Pisani, Antonio |
author_sort | Pisani, Valerio |
collection | PubMed |
description | BACKGROUND: Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at different stages of disease. METHODS: Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson’s disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood–brain barrier function. The group of patients with Parkinson’s disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4. RESULTS: Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values. CONCLUSIONS: Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood–brain barrier, or both, characterize Parkinson’s disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease. |
format | Online Article Text |
id | pubmed-3441323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34413232012-09-14 Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease Pisani, Valerio Stefani, Alessandro Pierantozzi, Mariangela Natoli, Silvia Stanzione, Paolo Franciotta, Diego Pisani, Antonio J Neuroinflammation Short Report BACKGROUND: Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson’s disease progression. However, few studies have addressed this issue in patients at different stages of disease. METHODS: Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson’s disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood–brain barrier function. The group of patients with Parkinson’s disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4. RESULTS: Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values. CONCLUSIONS: Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood–brain barrier, or both, characterize Parkinson’s disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease. BioMed Central 2012-08-08 /pmc/articles/PMC3441323/ /pubmed/22870899 http://dx.doi.org/10.1186/1742-2094-9-188 Text en Copyright ©2012 Pisani et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Pisani, Valerio Stefani, Alessandro Pierantozzi, Mariangela Natoli, Silvia Stanzione, Paolo Franciotta, Diego Pisani, Antonio Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
title | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
title_full | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
title_fullStr | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
title_full_unstemmed | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
title_short | Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease |
title_sort | increased blood-cerebrospinal fluid transfer of albumin in advanced parkinson’s disease |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441323/ https://www.ncbi.nlm.nih.gov/pubmed/22870899 http://dx.doi.org/10.1186/1742-2094-9-188 |
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