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Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains, leading to structural modifications that loosen the extracellular matrix barrier and associated with tumor metastasis, inflammation and angiogenesis. In addition, the highly sulfated heparan sulfate proteoglycans are imp...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441528/ https://www.ncbi.nlm.nih.gov/pubmed/23028487 http://dx.doi.org/10.1371/journal.pone.0044076 |