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The Natural Anticancer Agent Plumbagin Induces Potent Cytotoxicity in MCF-7 Human Breast Cancer Cells by Inhibiting a PI-5 Kinase for ROS Generation

Drug-induced haploinsufficiency (DIH) in yeast has been considered a valuable tool for drug target identification. A plant metabolite, plumbagin, has potent anticancer activity via reactive oxygen species (ROS) generation. However, the detailed molecular targets of plumbagin for ROS generation are n...

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Detalles Bibliográficos
Autores principales:	Lee, Ju-Hee, Yeon, Ji-Hyun, Kim, Hanna, Roh, Whijae, Chae, Jeiwook, Park, Han-Oh, Kim, Dong-Myung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441601/ https://www.ncbi.nlm.nih.gov/pubmed/23028742 http://dx.doi.org/10.1371/journal.pone.0045023

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