Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

Filoviruses, including Marburg virus (MARV) and Ebola virus (EBOV), cause fatal hemorrhagic fever in humans and non-human primates. All filoviruses encode a unique multi-functional protein termed VP35. The C-terminal double-stranded (ds)RNA-binding domain (RBD) of VP35 has been implicated in interfe...

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Detalles Bibliográficos
Autores principales: Bale, Shridhar, Julien, Jean-Philippe, Bornholdt, Zachary A., Kimberlin, Christopher R., Halfmann, Peter, Zandonatti, Michelle A., Kunert, John, Kroon, Gerard J. A., Kawaoka, Yoshihiro, MacRae, Ian J., Wilson, Ian A., Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441732/
https://www.ncbi.nlm.nih.gov/pubmed/23028316
http://dx.doi.org/10.1371/journal.ppat.1002916

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