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AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans

The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody...

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Detalles Bibliográficos
Autores principales:	Khurana, Surender, Frasca, Daniela, Blomberg, Bonnie, Golding, Hana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441753/ https://www.ncbi.nlm.nih.gov/pubmed/23028320 http://dx.doi.org/10.1371/journal.ppat.1002920

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