Rectal pH in Well and Unwell Infants

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Prompt antibiotic treatment for infants with sepsis has the potential to save lives. A rectal formulation of an antibiotic could be used at a village level before referral to hospital. The development of such a preparation needs to take into account the rectal pH of infants that will affect drug par...

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Detalles Bibliográficos
Autores principales: Turner, Claudia, Aye Mya Thein, Naw, Turner, Paul, Nosten, François, White, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442194/
https://www.ncbi.nlm.nih.gov/pubmed/21984527
http://dx.doi.org/10.1093/tropej/fmr088
Descripción
Sumario:Prompt antibiotic treatment for infants with sepsis has the potential to save lives. A rectal formulation of an antibiotic could be used at a village level before referral to hospital. The development of such a preparation needs to take into account the rectal pH of infants that will affect drug partitioning and absorption. Rectal pH measurements were taken in 100 well and 45 unwell infants. We also measured rectal pH in 14 infants sequentially over the course of their illness. The mean rectal pH was 6.75 with no significant difference in well or unwell infants. The mean (95% CI) rectal pH of well neonates was significantly lower than that of older infants (>28 days): 6.47 (6.29–6.65) vs. 6.90 (6.68 to 7.12) p = 0.003.

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