Cyclotherapy: opening a therapeutic window in cancer treatment

Cyclotherapy is a promising endeavor to improve cancer treatment by tackling the dose-limiting side effects of chemotherapy, especially for cancers harboring mutations in the TP53 tumor suppressor. In this particular context, pre-treatment with a p53 activator halts proliferation in healthy tissue,...

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Detalles Bibliográficos
Autor principal: van Leeuwen, Ingeborg M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442291/
https://www.ncbi.nlm.nih.gov/pubmed/22711025
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author van Leeuwen, Ingeborg M.M.
author_facet van Leeuwen, Ingeborg M.M.
author_sort van Leeuwen, Ingeborg M.M.
collection PubMed
description Cyclotherapy is a promising endeavor to improve cancer treatment by tackling the dose-limiting side effects of chemotherapy, especially for cancers harboring mutations in the TP53 tumor suppressor. In this particular context, pre-treatment with a p53 activator halts proliferation in healthy tissue, while leaving the p53-deficient tumor susceptible to conventional chemotherapy.
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spelling pubmed-34422912012-09-14 Cyclotherapy: opening a therapeutic window in cancer treatment van Leeuwen, Ingeborg M.M. Oncotarget Research Perspectives Cyclotherapy is a promising endeavor to improve cancer treatment by tackling the dose-limiting side effects of chemotherapy, especially for cancers harboring mutations in the TP53 tumor suppressor. In this particular context, pre-treatment with a p53 activator halts proliferation in healthy tissue, while leaving the p53-deficient tumor susceptible to conventional chemotherapy. Impact Journals LLC 2012-06-16 /pmc/articles/PMC3442291/ /pubmed/22711025 Text en Copyright: © 2012 van Leeuwen http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
van Leeuwen, Ingeborg M.M.
Cyclotherapy: opening a therapeutic window in cancer treatment
title Cyclotherapy: opening a therapeutic window in cancer treatment
title_full Cyclotherapy: opening a therapeutic window in cancer treatment
title_fullStr Cyclotherapy: opening a therapeutic window in cancer treatment
title_full_unstemmed Cyclotherapy: opening a therapeutic window in cancer treatment
title_short Cyclotherapy: opening a therapeutic window in cancer treatment
title_sort cyclotherapy: opening a therapeutic window in cancer treatment
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442291/
https://www.ncbi.nlm.nih.gov/pubmed/22711025
work_keys_str_mv AT vanleeuweningeborgmm cyclotherapyopeningatherapeuticwindowincancertreatment

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