Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation

Cells adapt to changes in ambient oxygen by changing their gene expression patterns. In fission yeast, the sterol regulatory element–binding protein Sre1 is proteolytically cleaved under low oxygen, and its N-terminal segment (Sre1N) serves as a hypoxic transcription factor. When oxygen is present,...

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Detalles Bibliográficos
Autores principales: Porter, Joshua R., Lee, Chih-Yung S., Espenshade, Peter J., Iglesias, Pablo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442422/
https://www.ncbi.nlm.nih.gov/pubmed/22833559
http://dx.doi.org/10.1091/mbc.E12-06-0451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442422/
https://www.ncbi.nlm.nih.gov/pubmed/22833559
http://dx.doi.org/10.1091/mbc.E12-06-0451

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