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Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation
Cells adapt to changes in ambient oxygen by changing their gene expression patterns. In fission yeast, the sterol regulatory element–binding protein Sre1 is proteolytically cleaved under low oxygen, and its N-terminal segment (Sre1N) serves as a hypoxic transcription factor. When oxygen is present,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442422/ https://www.ncbi.nlm.nih.gov/pubmed/22833559 http://dx.doi.org/10.1091/mbc.E12-06-0451 |