Cargando…
The role of inflammasome modulation in virulence
Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442838/ https://www.ncbi.nlm.nih.gov/pubmed/22546900 http://dx.doi.org/10.4161/viru.20266 |
| _version_ | 1782243482362970112 |
|---|---|
| author | Lupfer, Christopher R. Kanneganti, Thirumala-Devi |
| author_facet | Lupfer, Christopher R. Kanneganti, Thirumala-Devi |
| author_sort | Lupfer, Christopher R. |
| collection | PubMed |
| description | Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology. |
| format | Online Article Text |
| id | pubmed-3442838 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34428382012-09-26 The role of inflammasome modulation in virulence Lupfer, Christopher R. Kanneganti, Thirumala-Devi Virulence Review Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology. Landes Bioscience 2012-05-01 /pmc/articles/PMC3442838/ /pubmed/22546900 http://dx.doi.org/10.4161/viru.20266 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Review Lupfer, Christopher R. Kanneganti, Thirumala-Devi The role of inflammasome modulation in virulence |
| title | The role of inflammasome modulation in virulence |
| title_full | The role of inflammasome modulation in virulence |
| title_fullStr | The role of inflammasome modulation in virulence |
| title_full_unstemmed | The role of inflammasome modulation in virulence |
| title_short | The role of inflammasome modulation in virulence |
| title_sort | role of inflammasome modulation in virulence |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442838/ https://www.ncbi.nlm.nih.gov/pubmed/22546900 http://dx.doi.org/10.4161/viru.20266 |
| work_keys_str_mv | AT lupferchristopherr theroleofinflammasomemodulationinvirulence AT kannegantithirumaladevi theroleofinflammasomemodulationinvirulence AT lupferchristopherr roleofinflammasomemodulationinvirulence AT kannegantithirumaladevi roleofinflammasomemodulationinvirulence |