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Distinct degree of radiculopathy at different levels of peripheral nerve injury

BACKGROUND: Lumbar radiculopathy is a common clinical problem, characterized by dorsal root ganglion (DRG) injury and neural hyperactivity causing intense pain. However, the mechanisms involved in DRG injury have not been fully elucidated. Furthermore, little is known about the degree of radiculopat...

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Autores principales: Takiguchi, Noboru, Yoshida, Munehito, Taniguchi, Wataru, Hashizume, Hiroshi, Yamada, Hiroshi, Miyazaki, Nobuyuki, Nishio, Naoko, Nakatsuka, Terumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443045/
https://www.ncbi.nlm.nih.gov/pubmed/22537715
http://dx.doi.org/10.1186/1744-8069-8-31
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author Takiguchi, Noboru
Yoshida, Munehito
Taniguchi, Wataru
Hashizume, Hiroshi
Yamada, Hiroshi
Miyazaki, Nobuyuki
Nishio, Naoko
Nakatsuka, Terumasa
author_facet Takiguchi, Noboru
Yoshida, Munehito
Taniguchi, Wataru
Hashizume, Hiroshi
Yamada, Hiroshi
Miyazaki, Nobuyuki
Nishio, Naoko
Nakatsuka, Terumasa
author_sort Takiguchi, Noboru
collection PubMed
description BACKGROUND: Lumbar radiculopathy is a common clinical problem, characterized by dorsal root ganglion (DRG) injury and neural hyperactivity causing intense pain. However, the mechanisms involved in DRG injury have not been fully elucidated. Furthermore, little is known about the degree of radiculopathy at the various levels of nerve injury. The purpose of this study is to compare the degree of radiculopathy injury at the DRG and radiculopathy injury proximal or distal to the DRG. RESULTS: The lumbar radiculopathy rat model was created by ligating the L5 nerve root 2 mm proximal to the DRG or 2 mm distal to the DRG with 6.0 silk. We examined the degree of the radiculopathy using different points of mechanical sensitivity, immunohistochemistry and in vivo patch-clamp recordings, 7 days after surgery. The rats injured distal to the DRG were more sensitive than those rats injured proximal to the DRG in the behavioral study. The number of activated microglia in laminas I–II of the L5 segmental level was significantly increased in rats injured distal to the DRG when compared with rats injured proximal to the DRG. The amplitudes and frequencies of EPSC in the rats injured distal to the DRG were higher than those injured proximal to the DRG. The results indicated that there is a different degree of radiculopathy at the distal level of nerve injury. CONCLUSIONS: Our study examined the degree of radiculopathy at different levels of nerve injury. Severe radiculopathy occurred in rats injured distal to the DRG when compared with rats injured proximal to the DRG. This finding helps to correctly diagnose a radiculopathy.
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spelling pubmed-34430452012-09-15 Distinct degree of radiculopathy at different levels of peripheral nerve injury Takiguchi, Noboru Yoshida, Munehito Taniguchi, Wataru Hashizume, Hiroshi Yamada, Hiroshi Miyazaki, Nobuyuki Nishio, Naoko Nakatsuka, Terumasa Mol Pain Research BACKGROUND: Lumbar radiculopathy is a common clinical problem, characterized by dorsal root ganglion (DRG) injury and neural hyperactivity causing intense pain. However, the mechanisms involved in DRG injury have not been fully elucidated. Furthermore, little is known about the degree of radiculopathy at the various levels of nerve injury. The purpose of this study is to compare the degree of radiculopathy injury at the DRG and radiculopathy injury proximal or distal to the DRG. RESULTS: The lumbar radiculopathy rat model was created by ligating the L5 nerve root 2 mm proximal to the DRG or 2 mm distal to the DRG with 6.0 silk. We examined the degree of the radiculopathy using different points of mechanical sensitivity, immunohistochemistry and in vivo patch-clamp recordings, 7 days after surgery. The rats injured distal to the DRG were more sensitive than those rats injured proximal to the DRG in the behavioral study. The number of activated microglia in laminas I–II of the L5 segmental level was significantly increased in rats injured distal to the DRG when compared with rats injured proximal to the DRG. The amplitudes and frequencies of EPSC in the rats injured distal to the DRG were higher than those injured proximal to the DRG. The results indicated that there is a different degree of radiculopathy at the distal level of nerve injury. CONCLUSIONS: Our study examined the degree of radiculopathy at different levels of nerve injury. Severe radiculopathy occurred in rats injured distal to the DRG when compared with rats injured proximal to the DRG. This finding helps to correctly diagnose a radiculopathy. BioMed Central 2012-04-26 /pmc/articles/PMC3443045/ /pubmed/22537715 http://dx.doi.org/10.1186/1744-8069-8-31 Text en Copyright ©2012 Takiguchi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Takiguchi, Noboru
Yoshida, Munehito
Taniguchi, Wataru
Hashizume, Hiroshi
Yamada, Hiroshi
Miyazaki, Nobuyuki
Nishio, Naoko
Nakatsuka, Terumasa
Distinct degree of radiculopathy at different levels of peripheral nerve injury
title Distinct degree of radiculopathy at different levels of peripheral nerve injury
title_full Distinct degree of radiculopathy at different levels of peripheral nerve injury
title_fullStr Distinct degree of radiculopathy at different levels of peripheral nerve injury
title_full_unstemmed Distinct degree of radiculopathy at different levels of peripheral nerve injury
title_short Distinct degree of radiculopathy at different levels of peripheral nerve injury
title_sort distinct degree of radiculopathy at different levels of peripheral nerve injury
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443045/
https://www.ncbi.nlm.nih.gov/pubmed/22537715
http://dx.doi.org/10.1186/1744-8069-8-31
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