Functional Specialization in Proline Biosynthesis of Melanoma

Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then t...

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Detalles Bibliográficos
Autores principales: De Ingeniis, Jessica, Ratnikov, Boris, Richardson, Adam D., Scott, David A., Aza-Blanc, Pedro, De, Surya K., Kazanov, Marat, Pellecchia, Maurizio, Ronai, Ze'ev, Osterman, Andrei L., Smith, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443215/
https://www.ncbi.nlm.nih.gov/pubmed/23024808
http://dx.doi.org/10.1371/journal.pone.0045190

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