IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection

The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured I...

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Autores principales: Ruhwald, Morten, Andersen, Ellen Sloth, Christensen, Peer Brehm, Moessner, Belinda Klemmensen, Weis, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443225/
https://www.ncbi.nlm.nih.gov/pubmed/23024806
http://dx.doi.org/10.1371/journal.pone.0045181
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author Ruhwald, Morten
Andersen, Ellen Sloth
Christensen, Peer Brehm
Moessner, Belinda Klemmensen
Weis, Nina
author_facet Ruhwald, Morten
Andersen, Ellen Sloth
Christensen, Peer Brehm
Moessner, Belinda Klemmensen
Weis, Nina
author_sort Ruhwald, Morten
collection PubMed
description The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p<0.0001). The DPS based method for IP-10 detection performs well in HCV-infected patients with either minimal or significant fibrosis.
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spelling pubmed-34432252012-09-28 IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection Ruhwald, Morten Andersen, Ellen Sloth Christensen, Peer Brehm Moessner, Belinda Klemmensen Weis, Nina PLoS One Research Article The chemokine IP-10 (CXCL10) is a candidate marker for hepatitis C virus (HCV) fibrosis monitoring. The aim of this proof-of-concept study is to assess if IP-10 measurements from dried plasma spots (DPS) are accurate in HCV-infected patients with either minimal or significant fibrosis. We measured IP-10 levels in plasma and DPS of 21 HCV-infected patients with cirrhosis and 19 patients with no/little fibrosis (determined with FibroScan). Cirrhotic patients had significantly higher levels of IP-10 compared to patients with minimal fibrosis. DPS and plasma measurements of IP-10 are comparable and the correlation was excellent (r(2) = 0.97, p<0.0001). The DPS based method for IP-10 detection performs well in HCV-infected patients with either minimal or significant fibrosis. Public Library of Science 2012-09-14 /pmc/articles/PMC3443225/ /pubmed/23024806 http://dx.doi.org/10.1371/journal.pone.0045181 Text en © 2012 Ruhwald et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ruhwald, Morten
Andersen, Ellen Sloth
Christensen, Peer Brehm
Moessner, Belinda Klemmensen
Weis, Nina
IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
title IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
title_full IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
title_fullStr IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
title_full_unstemmed IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
title_short IP-10 Can Be Measured in Dried Plasma Spots in Patients with Chronic Hepatitis C Infection
title_sort ip-10 can be measured in dried plasma spots in patients with chronic hepatitis c infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443225/
https://www.ncbi.nlm.nih.gov/pubmed/23024806
http://dx.doi.org/10.1371/journal.pone.0045181
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